Effects of antibiotic administration on the composition of the human intestinal...
Effects of antibiotic administration on the composition of the human intestinal microbiota the prevalence of antibiotic resistant bacteria and the development of antibiotic associated diarrhoea
Antibiotics remain valuable agents to fight infectious disease, but can also affect the normal gastrointestinal tract (GIT) microbiota resulting in detrimental symptoms. Despite the long therapeutic use of antibiotics, it is still...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
ANTIRESDEV
The effects of antibiotic administration on the emergence an...
7M€
Cerrado
SAF2014-60234-R
ESTUDIO DEL EFECTO PROTECTOR DEL MICROBIOMA FRENTE A INFECCI...
194K€
Cerrado
IAPEMIDE
Impact of Intrapartum Antimicrobial Prophylaxis as an early...
158K€
Cerrado
PID2021-127477OB-I00
DESVELANDO LA GENOMICA DE LAS BACTERIAS ANAEROBIAS PROCEDEN...
109K€
Cerrado
MUCDIFF
Competition between the enteric pathogen Clostridium diffici...
166K€
Cerrado
PDC2021-121808-I00
DESARROLLO DE UN PROBIOTICO PARA COMBATIR INFECCIONES PRODUC...
144K€
Cerrado
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Antibiotics remain valuable agents to fight infectious disease, but can also affect the normal gastrointestinal tract (GIT) microbiota resulting in detrimental symptoms. Despite the long therapeutic use of antibiotics, it is still unclear which components of the anaerobic gut microbiota are affected causing the development of antibiotic-associated diarrhoea (AAD), one of the most frequent side effects of antibiotic intake. It is also unknown whether the reduced number of commensal bacteria is sufficient to favour pathogen colonization, including by the most pathogenic agent linked to AAD, Clostridium difficile, or whether other conditions in the GIT change to promote pathogen colonization. The objectives of this proposal are (1) to rapidly monitor variations in the structure of the colonic microbial community thus identifying any population shifts due to tetracycline (Tc) therapy in human acne sufferers, (2) to investigate the effect of Tc treatment and other gut parameters on specific gene expression and the colonization ability of C. difficile isolates, and (3) to monitor changes in the occurrence and prevalence of specific tetracycline resistance (TcR) genes following long-term Tc treatment. The combination of the molecular ecology, molecular genetics and transcriptomic approaches that will be applied in this proposal will provide us with a deeper understanding of the role played by the GIT microbiota in human health, including how pathogens may gain control of the GIT ecosystem following antibiotic therapy, and finally of the contribution made by commensal GIT bacteria to the dissemination and emergence of bacterial antibiotic resistance.