Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

TOGETHER

Financiado

Cerrado

E Pluribus Unum Principles and Plasticity of Electrical Coupling in a Neuronal...

E Pluribus Unum Principles and Plasticity of Electrical Coupling in a Neuronal Network The complex network activity patterns of the CNS result from an interplay between intrinsic neuronal properties and the connections formed by component cells. Connectivity is most commonly considered in terms of the classical chem... ver más

30/09/2026

STOCKHOLMS UNIVERS...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

STOCKHOLMS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-07-14

ERC-2020-ADG: ERC ADVANCED GRANT Specific Challenge:Objectives

I+D

Cerrada

0% 100% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

STOCKHOLMS UNIVERSITET

2.22M€ | Lider

APC SYSTEMS BCN

350.00K€ | Participante

Proyectos interesantes

DMANDYB ASTROMORPH

Medical Technol...

Applied Physics

182K€ Cerrado

SAF2009-11614

Medical Technol...

Applied Physics

194K€ Cerrado

MTM2015-71509-C2-2-R

Medical Technol...

Applied Physics

22K€ Cerrado

FUELLINGSYNAPSES

Medical Technol...

Applied Physics

2M€ Cerrado

BFU2008-04196

Medical Technol...

Applied Physics

73K€ Cerrado

Nano-axo-syn

Medical Technol...

Applied Physics

213K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 62 meses Fecha Inicio: 2021-07-14
Fecha Fin: 2026-09-30

Líder del proyecto

STOCKHOLMS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The complex network activity patterns of the CNS result from an interplay between intrinsic neuronal properties and the connections formed by component cells. Connectivity is most commonly considered in terms of the classical chemical synapse. It is now clear, however, that electrical synapses formed by intercellular connexin channels in gap junctions (GJs) are widespread in the mammalian CNS and critically influence circuit activity. But exactly how GJs shape brain output, and how electrical coupling is regulated over different time-scales remains elusive. In the proposed project, we will take advantage of a recently discovered species difference between hypothalamic tuberoinfundibular dopamine (TIDA) neurons in the rat and mouse, to address these issues. In the rat, TIDA neurons are connected by strong GJs and exhibit a slow network oscillation; in the mouse the same cells completely lack electrical synapses and oscillate faster, a difference that ultimately leads to different male parenting phenotypes. Using the TIDA system as a platform, we will examine: I) What happens to TIDA neuronal properties and the male paternal circuit when GJs are removed from the coupled circuit, or when uncoupled cells are joined by electrical synapses? II) Does the pregnant dam prepare for motherhood by decoupling the TIDA network? III) Does electrical coupling fluctuate across neuronal oscillations? What are the mechanisms and consequences for circuit output? IV) Which organizing principles are conferred onto a network by the presence of GJs? These issues will be addressed by a combination of in vitro electrophysiology, imaging, voltammetry, behavioural paradigms and molecular analysis for a comprehensive investigation of GJ function and modulation. By leveraging the unique experiment of nature offered by the rodent TIDA system, the proposed project will address core issues of electrical coupling that have long remained out of reach for experimental scrutiny.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores