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TEI

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Development of a model system to study the role of chromatin factors during tran...

Development of a model system to study the role of chromatin factors during transgenerational epigenetic inheritance TEI in C. elegans Non DNA-sequence based inheritance has been observed in many organisms from microbes to man and likely impacts public health. The mechanisms of non DNA-sequence based inheritance remain largely unknown. However, some examples of n... ver más

30/04/2019

THE CHANCELLOR MAS...

183K€

Presupuesto del proyecto: 183K€

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TRL 4-5

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-04-30

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Duración del proyecto: 25 meses Fecha Inicio: 2017-03-20
Fecha Fin: 2019-04-30

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Non DNA-sequence based inheritance has been observed in many organisms from microbes to man and likely impacts public health. The mechanisms of non DNA-sequence based inheritance remain largely unknown. However, some examples of non DNA-sequence based inheritance in mammals, plants and invertebrates are linked to the control of selfish, transposable elements in the genome. Here we propose to discover the mechanistic basis of multi-generational non DNA-sequence based inheritance, also referred to as transgenerational epigenetic inheritance (TEI), using the laboratory animal model Caenorhabditis elegans. Specifically, our goal is to identify chromatin and non-coding RNA epigenetic marks that transfer information from generation to generation in C. elegans. C. elegans is a great model for this work as it has a generation time of only three days, has a powerful genetics toolkit and its chromatin and RNA pathways are largely conserved in humans. Towards this goal we have established a novel assay we named piRNA-related insertional chromatin immunoprecipitation (piChIP). Using this piChIP system, our specific aims are: Aim-1: Identification of novel non-coding RNAs in the germline nuclear RNAi pathway - Method: RNA-seq Aim-2: Identification of novel proteins and histone PTMs in the germline nuclear RNAi pathway - Method: SILAC proteomics and Mass Spectrometry

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