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RNAflashbacks

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The Neuronal Code of Inheritance
Little is known about non-DNA mediated transgenerational inheritance of parental responses. If inheritance of non-genetic materials is prevalent, it could challenge our conceptions regarding the rules and limits of heredity. We ar... Little is known about non-DNA mediated transgenerational inheritance of parental responses. If inheritance of non-genetic materials is prevalent, it could challenge our conceptions regarding the rules and limits of heredity. We are in particularly intrigued by the possibility that the nervous system can produce heritable changes. Mechanisms for propagation of responses from the soma to the germline are known. Until very recently, the possibility that any type of environmental response could become heritable, let alone somatic responses, was considered blasphemous. In C. elegans nematodes, exogenously-supplied artificial dsRNA transfers from the soma to the germline, triggering transgenerational small RNA-mediated RNA interference. It is unknown whether endogenous small RNAs can transmit specific information about the environment to the progeny. We will investigate if endogenous siRNAs, which are naturally made in somatic tissues, and in particular in neurons, produce transgenerational responses. Specifically, we will test which RNA molecules act transgenerationally, how do they mediate non-cell autonomous gene regulation, and which responses can be communicated to the progeny. What is the code that transforms particular environmental responses to specific arsenals of heritable RNA molecules? We will answer these questions, and moreover study the implications that this completely new form of hereditary has for the offspring’s survival. Can heritable small RNAs retain adaptive memory? Not only will we elucidate natural transmission of the parents’ activity from generation-to-generation, we will moreover devise means to control these mechanisms. We will engineer tools to diagnose, erase, maintain, and modulate the heritable effects, which would be important for basic research and hopefully also translational in the future. ver más
31/07/2025
TAU
2M€
Perfil tecnológico estimado
Duración del proyecto: 76 meses Fecha Inicio: 2019-03-05
Fecha Fin: 2025-07-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2019-03-05
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2018-COG: ERC Consolidator Grant
Cerrada hace 6 años
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
TEL AVIV UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5