Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

DrosoParamutation

Financiado

Unraveling the role of transgenerational epigenetic inheritance mediated by para...

Unraveling the role of transgenerational epigenetic inheritance mediated by paramutation in natural animal populations. Understanding how organisms rapidly adapt to changing environments is a fundamental question in evolutionary biology. Transgenerational epigenetic inheritance (TEI) has been proposed as a mechanism that allows organisms to respond... ver más

15/11/2026

CSIC

181K€

Presupuesto del proyecto: 181K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-13

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada hace 1 año

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CSIC

181.15K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BES-2014-070987 PATRONES DE VARIACION GENETICA EN DROSOPHILA: VARIACION GEOG... 88K€ Cerrado

RYC-2010-07114 Evolution and transgenerational inheritance of chromatin sta... Cerrado

BES-2016-079161 DE LOS GENES A LAS CELULAS Y DE LAS CELULAS A LOS ORGANOS EN... Cerrado

BES-2009-020962 REPRESION TRANSCRIPCIONAL DURANTE EL DESARROLLO DE DROSOPHIL... 43K€ Cerrado

BES-2010-030149 ANALISIS BIOQUIMICO DE GENES QUE REGULAN LA EXPRESION GENICA... 43K€ Cerrado

BFU2008-04988 GENOMICA COMPARADA Y FUNCIONAL DE DROSOPHILA: CAUSAS Y CONSE... 292K€ Cerrado

Duración del proyecto: 32 meses Fecha Inicio: 2024-03-13
Fecha Fin: 2026-11-15

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 181K€

Descripción del proyecto Understanding how organisms rapidly adapt to changing environments is a fundamental question in evolutionary biology. Transgenerational epigenetic inheritance (TEI) has been proposed as a mechanism that allows organisms to respond flexibly to environmental variation and thus plays a central role in rapid adaptation to fluctuating environments. A compelling example of this process is paramutation, in which epigenetic information is transferred from one allele to another, leading to heritable changes in gene expression across generations. However, our understanding of paramutation in natural animal populations remains limited, with most evidence coming from laboratory models. This knowledge gap hinders our understanding of the role of paramutation in nature. Here, we will study paramutation in different natural populations of Drosophila melanogaster to investigate its potential to drive transgenerational epigenetic inheritance and gene expression variation that can shape evolution. We will investigate the responsiveness of paramutation to environmental changes and its heritable stability across generations. We will also establish a model to dissect the molecular mechanisms of paramutation regulation, assessing the role of insulator proteins such as Su(Hw) and 3D chromatin conformation. This project will provide a comprehensive investigation of the role of paramutation in natural animal populations at multiple levels of information, including genetics, epigenetics, gene expression, and 3D chromatin structure. This research proposal aims not only to determine the biological relevance of a case of transgenerational epigenetic inheritance such as paramutation in natural animal populations but more importantly to provide an excellent model system for its in-depth molecular dissection.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores