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PID2020-114086RB-I00

Financiado

DESARROLLOS BASADOS EN POLIFENOLES PARA RETOS CLINICOS EN MEDICINA REGENERATIVA...

DESARROLLOS BASADOS EN POLIFENOLES PARA RETOS CLINICOS EN MEDICINA REGENERATIVA PENDIENTES DE RESOLVER REGENERATIVE MEDICINE (RM) IS AN INTERDISCIPLINARY FIELD OF RESEARCH FOCUSED ON THE REPAIR AND REGENERATION OF DAMAGED TISSUES AND ORGANS AT THE CELLULAR LEVEL BY THE STIMULATION OF THE BODYS OWN REPAIR MECHANISMS. THE IDEAL RM T... ver más

01/01/2020

CSIC

194K€

Presupuesto del proyecto: 194K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2020-01-01 No tenemos la información de la convocatoria

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CSIC

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Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 194K€

Descripción del proyecto REGENERATIVE MEDICINE (RM) IS AN INTERDISCIPLINARY FIELD OF RESEARCH FOCUSED ON THE REPAIR AND REGENERATION OF DAMAGED TISSUES AND ORGANS AT THE CELLULAR LEVEL BY THE STIMULATION OF THE BODYS OWN REPAIR MECHANISMS. THE IDEAL RM TREATMENT IS THE ONE THAT CLOSEST MIMIC THE BODY TISSUES OF A HEALTHY HUMAN, BEING AUTOGRAFTS AND ALLOGRAFTS ONE OF THE MAIN OPTIONS; HOWEVER, THESE TREATMENTS PRESENT SEVERAL DISADVANTAGES; CONSEQUENTLY, DEVELOPMENT OF ENGINEERING SUPPORTS EMERGED IN LATER YEARS AS NEW THERAPIES AND MANY COMMERCIALLY AVAILABLE TISSUE ENGINEERING PRODUCTS ARE IN THE MARKET AND USED CLINICALLY AT PRESENT. DESPITE THEIR REASONABLE SUCCESS, STILL MUCH OF THEM FAIL TO RESTORE AND REPAIR THE TISSUES WITH EXTRACELLULAR MATRIX SIMILAR TO NATIVE ONES. THIS IS THE CASE OF SOME COMMERCIALLY AVAILABLE CARTILAGE ENGINEERING PRODUCTS WHICH LEAD TO FORMATION OF FIBROCARTILAGE INSTEAD OF HYALINE CARTILAGE OR EVEN MOST OF THE ENGINEERING DERMIC AND EPIDERMIC GRAFTS CLINICALLY APPLIED THAT DO NOT PAY ATTENTION TO THE INFLAMMATION MODULATION, PATHOGENIC MICROORGANISM PROLIFERATION OR PROMOTION OF A BALANCED MICROBIOTA. IN THIS CONTEXT, THE AIM OF POLYPHILLED LIES IN THE DEVELOPMENT OF BIOMIMETIC SUBSTITUTES BASED ON NATURAL POLYMERS AND POLYPHENOLS WITH ANTIMICROBIAL, ANTI-INFLAMMATORY AND BIOADHESIVE PROPERTIES. THESE MATERIALS WILL BE COMBINED WITH OTHER BIOACTIVE MOLECULES, DRUGS, MESENCHYMAL STROMAL CELLS (MSC) SECRETOME OR LIVING BACTERIA WITH ADDITIONAL OR SYNERGISTIC PROPERTIES. THEY WILL BE MANUFACTURED IN SUCH A WAY THAT THEIR MICROSTRUCTURE AND ARCHITECTURE REPRODUCE, AS MUCH AS POSSIBLE, THE NATIVE TISSUE. THUS, POLYPHILLED WILL DEVELOP NEW SYSTEMS FOR THE REGENERATION OF CARTILAGE AND SKIN LESIONS OF DIFFERENT CHARACTERISTICS. THE PROPOSAL STEMS FROM TWO PILLARS. RESPECT TO MATERIALS SCIENCE: I) THE SYSTEMS WILL BE DEVELOPED FROM NATURAL POLYMERS OBTAINED FROM RENEWABLE SOURCES THAT WILL BE CONJUGATED OR CROSS-LINKED WITH POLYPHENOLIC COMPOUNDS SUCH AS EPIGALLOCATECHIN-3-O-GALLATE, ROSMARINIC ACID OR TANNIC ACID; II) THE SYSTEMS CAN ALSO BE LOADED WITH COMPLEMENTARY ANTI-INFLAMMATORY COMPOUNDS, SUCH AS COENZYME Q10 (Q10) OR ANTI-INFLAMMATORY DRUGS (CORTICOIDS AND COXIBS), THAT ADDITIONALLY ARE INVOLVED IN THE TISSUE REPAIR PROCESSES. THESE COMPOUNDS WILL BE ENCAPSULATED IN NANOPARTICLES OF THE FUNCTIONALIZED POLYMERS; III) SELECTED SYSTEMS WILL BE ENDOWED WITH AGENTS THAT PROVIDE METABOLIC BENEFITS (I.E. ZN2+), OTHER SYSTEMS WILL CONTAIN MSC-DERIVED SECRETOME, OR COMMENSAL BACTERIA OF SKIN MICROBIOTA (IN THIS PROJECT S. EPIDERMIDIS WILL BE USED AS A PROOF OF CONCEPT). RESPECT TO THE SUPPORT MICROSTRUCTURE/ARCHITECTURE, MATERIALS WILL BE PREPARED TAKING INTO CONSIDERATION THEIR SPECIFIC APPLICATION AS I) HYDROGELS WITH SUPRAMOLECULAR STRUCTURE TO REPAIR CARTILAGE IN ARTHROSIS DISEASE; II) WELL-DEFINED-STRUCTURED ELECTROSPUN SUPPORTS TO REPAIR OSTEOCHONDRAL DEFECTS THAT ARE TREATED BY MICROFRACTURE TECHNIQUE; AND III) SYSTEMS BASED ON POLYELECTROLYTE COMPLEXES (MANUFACTURED BY LAYER-BY-LAYER METHODOLOGY) DEVOTED TO SKIN TISSUE ENGINEERING MEDICINE OF DIFFERENT SKIN LESIONS. SUPPORTS GATHERING ALL THESE CHARACTERISTICS TOGETHER ARE EXPECTED TO ACHIEVE TISSUES (I.E. CARTILAGE OR SKIN) WITH SIMILAR CHARACTERISTICS TO THOSE OF NATIVE ONES, IN THE FRAME OF SOME OF THE UNFULFILLED CLINICAL CHALLENGES MENTIONED ABOVE. OLIFENOLES\ESTUDIOS IN VIVO\CARACTER ANTIMICROBIANO\ACTIVIDAD ANTI-INFLAMATORIA\PROPIEDADES ANTIOXIDANTES\POLIMEROS NATURALES\BIOADESION

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