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Contribution of Lipid Droplets to the pathogenesis and chemoresistance of Acute...

Contribution of Lipid Droplets to the pathogenesis and chemoresistance of Acute Myeloid Leukemia Acute Myeloid Leukemia (AML) results from the uncontrolled expansion of differentiation-defective hematopoietic stem/progenitor cells or immature myeloid cells (blasts) in the bone marrow (BM). AML remains a high-risk disease main... ver más

28/02/2026

FUNDACIO INSTITUT...

226K€

Presupuesto del proyecto: 226K€

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FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEM... Actividades de investigación asociacion

TRL 4-5 | 50K€

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-27

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

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Cerrada hace 3 años

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2 Participantes

FUNDACIO INSTITUT DE RECERCA...

226.44K€ | Lider

ONECHAIN IMMUNOTHERAPEUTICS...

N.D. | Participante

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Duración del proyecto: 44 meses Fecha Inicio: 2022-06-27
Fecha Fin: 2026-02-28

Líder del proyecto

FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEM... Actividades de investigación asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 226K€

Descripción del proyecto Acute Myeloid Leukemia (AML) results from the uncontrolled expansion of differentiation-defective hematopoietic stem/progenitor cells or immature myeloid cells (blasts) in the bone marrow (BM). AML remains a high-risk disease mainly due to treatment refractoriness which is dependent on leukemia-BM stroma interactions. Unfortunately, treatments have only experienced minor developments over the last decades. On the other hand, emerging evidence in cancer metabolism has identified Lipid Droplets (LDs, cytosolic fat storage organelles) as key regulators of lipid metabolism and signalling in cells exposed to stress such as hypoxia, chemotherapy, and nutrient deprivation. However, the precise role of LDs in the pathogenesis and chemoresistance of AML remains poorly investigated. Here, we aim to i) characterize the accumulation and role of LDs in AML, ii) assess the functional impact of blasts- and BM stroma-LDs on AML pathogenesis and chemoresistance, and iii) investigate the involvement of LDs in the progression and refractoriness of AML. Cutting-edge in vitro (AML primary cells, BM-stroma cells) and in vivo assays (patient-derived xenografts) will be used to provide evidence of LDs as a key player in leukemogenesis. Our project is based on solid preliminary single cell-RNA sequencing data indicating that LDs are highly accumulated in AML blasts, and that inhibition of LDs is more effective than the standard-of-care chemotherapy in impairing AML cell proliferation. Our proposal represents an innovative approach achievable thanks to the complementary knowledge and expertise of two top-notch laboratories in acute leukemia (supervisor) and LDs (collaborator). Results from this study will open new avenues to explore the therapeutic opportunity of LD inhibitors as anti-leukemic co-adjuvant. This fellowship will enable me to acquire transformational knowledge in leukemia metabolism and will constitute a major first step towards initiating my independent academic career.

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