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MetEpiClock

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Circadian Control of Histone Methylation Dynamics through the Fine tuning of Met...

Circadian Control of Histone Methylation Dynamics through the Fine tuning of Methionine Metabolic Flux The circadian clock directs almost all aspects of diurnal physiology, including metabolism. Defects in circadian rhythms influence physiology and behavior with implications for numerous pathological conditions, including cancer, m... ver más

01/10/2022

HUNIMED

262K€

Presupuesto del proyecto: 262K€

Líder del proyecto

HUMANITAS UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-10-01

MSCA-IF-2016: Individual Fellowships

I+D

Cerrada hace 8 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

HUNIMED

262.27K€ | Lider

THE REGENTS OF THE UNIVERSIT...

LOS ANGELES UCLA SANTA BARBA...

172.13K€ | Participante

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Duración del proyecto: 66 meses Fecha Inicio: 2017-03-17
Fecha Fin: 2022-10-01

Líder del proyecto

HUMANITAS UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 262K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The circadian clock directs almost all aspects of diurnal physiology, including metabolism. Defects in circadian rhythms influence physiology and behavior with implications for numerous pathological conditions, including cancer, metabolic syndrome, obesity, diabetes and cardiovascular diseases. By controlling metabolic homeostasis at the cellular level, the clock can directly influence cellular regulatory networks, including those that govern chromatin dynamics. The goal of this proposal is to investigate if metabolic pathways able to influence gene expression via chromatin dynamics are under circadian control and whether these regulatory networks are crucial for the maintenance of a correct metabolic homeostasis. We will test if the clock governs the methylation potential of the cell by regulating the diurnal expression of rate-limiting enzymes of methionine metabolism. By using metabolite restriction, pharmacological and gene editing approaches we will disrupt circadian rhythmicity of SAM and SAH. We will then use state-of-the-art methods including, transcriptomics, epigenomics and metabolomics to investigate the impact of this regulatory network on circadian transcriptional regulation, histone methylation dynamics and metabolic homeostasis. By dissecting how circadian regulation, metabolism and epigenetics are interconnected we will gain novel insights into how these factors contribute to normal physiology and disease. At UCI I will exploit the expertise of the outgoing supervisor in the area of circadian biology, molecular metabolism and epigenetics. Then, at Humanitas University I will refine the knowledge and skills acquired during the outgoing phase, with the final aim of applying them to the cardiovascular field. This will place me in a privileged position to establish myself as a competent researcher within the European Community, in the field of cardiovascular biology, metabolism and epigenetics.

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