Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

NPCvalve

Financiado

Beyond nucleocytoplasmic transport – Nuclear pores as self-regulating valves for...

Beyond nucleocytoplasmic transport – Nuclear pores as self-regulating valves for flux across the nuclear envelope Nuclear pore complexes (NPCs) are fundamental components of all eukaryotic cells. They fuse the inner and outer nuclear membranes and form channels across the nuclear envelope. Their canonical function as gatekeepers of the nucleu... ver más

31/01/2028

MPG

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-05-04

ERC-2021-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

MPG

2.12M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2020-116404GB-I00 CARACTERIZACION DE LA DIVERSIDAD DEL COMPLEJO DEL PORO NUCLE... 224K€ Cerrado

NPC-BUILD The Nuclear Pore Basket Functional Architecture of a Membr... 2M€ Cerrado

BFU2008-01344 ESTRUCTURA DE MAQUINAS MOLECULARES IMPLICADAS EN DINAMICA CR... 417K€ Cerrado

FIS2015-62527-ERC IMAGEN DE LOS PROCESOS DE LA VIDA 30K€ Cerrado

TuningTracks Tuning the Tracks: Resolving the interplay between microtubu... 188K€ Cerrado

cryoSPARTAN in situ Structure Determination of Actin-binding Proteins Th... 199K€ Cerrado

Duración del proyecto: 68 meses Fecha Inicio: 2022-05-04
Fecha Fin: 2028-01-31

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Nuclear pore complexes (NPCs) are fundamental components of all eukaryotic cells. They fuse the inner and outer nuclear membranes and form channels across the nuclear envelope. Their canonical function as gatekeepers of the nucleus and facilitators of nucleocytoplasmic exchange is well established. I hypothesize that NPCs fulfil yet another fundamental function as self-regulating valves for flux across the nuclear envelope that occurs in response to mechanical stress. This yet underappreciated function may be of utmost importance to prevent rupture of the nuclear envelope and thus to protect the genomic integrity in cells that are exposed to mechanical stress. I present preliminary data indicating that NPC conformation responds to mechanical force exerted onto the nuclear envelope with dilation and constriction. Cryo-electron tomography, live cell imaging, and genetic perturbation will be used jointly with structural modelling to investigate on a holistic scale how NPC diameter and nuclear envelope tension impact on flux across the nuclear envelope. In the proposed project I will demonstrate that besides their known function as transport channels the NPCs serve an important role as shock adsorbers for mechanical stress impacting the nucleus. The research proposed here will enhance our understanding of how cells deal with acute mechanical stress which is relevant for cell migration, metastasis, mechanically active tissues and cell differentiation.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores