Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SYNTHECYCLE

Financiado

Cerrado

Architecture and logic of the eukaryotic cell cycle

"Our knowledge of the functioning of eukaryotic cells has emerged from thorough investigation of the molecular mechanisms driving cellular events. However, the complexity of the underlying regulatory networks has made it difficult... ver más

31/12/2017

CNRS

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-12-31 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CNRS

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ChromaDYN Quantitative multimodal pulse-and-label time-resolved chroma... 2M€ Cerrado

BFU2013-46923-P LA SALIDA DE MITOSIS EN LA LEVADURA DE FISION S. POMBE. ULTI... 169K€ Cerrado

SYNTHEYEAST Design principles and variability control in a central eukar... 100K€ Cerrado

BIO2011-28941-C03-01 BIOLOGIA SINTETICA DE LA DIVISION 303K€ Cerrado

PRE2020-093229 BIOLOGIA SINTETICA DE ELEMENTOS REGULADORES DE GENES MEDIANT... 99K€ Cerrado

CONSYN Contextualizing biomolecular circuit models for synthetic bi... 2M€ Cerrado

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Our knowledge of the functioning of eukaryotic cells has emerged from thorough investigation of the molecular mechanisms driving cellular events. However, the complexity of the underlying regulatory networks has made it difficult to understand the core control of essential functions. In the same way that model organisms were chosen for their ease of manipulation or simplicity, model pathways need to be developed to decipher the design principles of regulatory circuits. Using fission yeast, I demonstrated the possibility to replace cell cycle control by a simple synthetic system in vivo and proposed a novel paradigm for the core cell cycle engine. This established the foundation for the proposed projects, which use a synthetic approach to dissect the organisation, complexity and evolution of cellular reproduction. Our work will focus on four axes of research. First, we will investigate the properties of the cyclin dependent kinase (CDK) circuit that ensure reproducibility of cell cycle sequence between cells. Next, we will assess CDK activity dynamics and study their role in progression through cell cycle transitions as well as in the maintenance of population homogeneity. Third, we will investigate the rationale behind the complexity in cell cycle control observed in modern cells, as my previous work has demonstrated that entire branches of the network are dispensable. This will finally lead us to take a unique approach to explore evolutionary principles, assessing how cells operating with simplified CDK circuits adapt and overcome defects in cell cycle progression. These studies relying on mathematical modelling and synthetic rewiring of cell cycle control will shed light on fundamental aspects of this essential process and bring new perspectives to our understanding of its evolution. As cell cycle progression is a foundation of cellular life, our work will have important implications for multicellular organisms and pathological situations."

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores