Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

AGORAs

Financiado

Cerrado

AGeing effects on human aORta from shApe to flowS

Age-related remodeling of the aorta is associated with alterations in morphology and hemodynamics . These alterations are involved and accelerated in the presence of cardiovascular diseases (CVDs), suggesting that they are the lik... ver más

15/05/2019

POLITO

230K€

Presupuesto del proyecto: 230K€

Líder del proyecto

POLITECNICO DI TORINO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-05-15

MSCA-IF-2014-GF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 10 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

POLITO

229.76K€ | Lider

THE GOVERNING COUNCIL OF THE...

UNIVERSITY OF TORONTO

145.62K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MaPViAH Electroanatomical exploration of pulmonary veins sleeve myoc... 231K€ Cerrado

MODELAGE Is your heart aging well? A systems biology approach to char... 1M€ Cerrado

FIS2010-19860 DIAGNOSTICO DE ANEURISMAS DE AORTA MEDIANTE NUEVAS TECNICAS... 85K€ Cerrado

FibreRemodel Frontier research in arterial fibre remodelling for vascular... 2M€ Cerrado

SAF2012-40208 EFECTOS FUNCIONALES Y MOLECULARES DE DISTINTAS FORMAS DE HDL... 94K€ Cerrado

MERC Molecular mechanisms regulating cardiovascular remodeling by... 170K€ Cerrado

Duración del proyecto: 42 meses Fecha Inicio: 2015-10-30
Fecha Fin: 2019-05-15

Líder del proyecto

POLITECNICO DI TORINO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 230K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Age-related remodeling of the aorta is associated with alterations in morphology and hemodynamics . These alterations are involved and accelerated in the presence of cardiovascular diseases (CVDs), suggesting that they are the likely culprits that underlie the increased cardiovascular risk associated with ageing . However, an advanced characterization of the age-related morphological/hemodynamic alterations and on their synergistic interplay is missing, mainly because encumbered by time-consuming operator-dependent tasks. In this 36 months global fellowship (University of Toronto, Canada and Politecnico di Torino, Italy), the potential clinical utility of such a characterization will be addressed, developing tools for the quantitative assessment of the age-associated alterations in a large-scale cross-sectional dataset of aortas from subjects with successful ageing. After training on phase-contrast magnetic resonance imaging (PCMRI) technique, for each subject the 4D velocity field will be acquired. Quantitative morphometric parameters will be defined and evaluated in vivo. To investigate aortic hemodynamics, PCMRI will be complemented by computational fluid dynamics (CFD) to overcome PCMRI limitations on temporal/spatial resolution and wall shear stress quantification . The impact of CFD assumptions will be assessed by validating CFD results with PCMRI measurements. To improve CFD results accuracy, in the return phase PCMRI data will be incorporated into the numeric simulations, through the assimilation of the acquired flow fields into the CFD solver. Descriptors quantifiable in vivo and able to simplify the understanding of the complex 4D hemodynamic and of age-associated remodeling will be defined. The new tools for diagnostic/prognostic purposes will be integrated within the open-source Vascular Modelling ToolKit, to facilitate and streamline the diagnosis and monitoring of a wider range of CVDs when applied to other vascular districts (e.g. carotid, aneurysm).

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores