Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CARBOCENTRE

Financiado

Activity Based Profiling of Glycoprocessing Enzymes for Human Health and a Susta...

Activity Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society Enzymes that produce and degrade oligosaccharides and glycoconjugates are present in all kingdoms of life. The ability to visualize, modulate and understand these carbohydrate-active enzymes (CAZymes) therefore offers great potent... ver más

31/05/2027

ULEI

9M€

Presupuesto del proyecto: 9M€

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 4 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-12-18

ERC-2020-SyG: ERC Synergy Grant

I+D

Cerrada hace 5 años

0% 100% 100%

4 Participantes

ULEI

3.77M€ | Lider

BENECKE-KALIKO

1.98M€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

SWEETOOLS Smart Biologics Developing New Tools in Glycobiology 1M€ Cerrado

PID2021-123332OB-C22 BIOCATALISIS COMPUTACIONAL: UNA APROXIMACION AL DISEÑO RACIO... 131K€ Cerrado

CTQ2009-11801 SINTESIS QUIMIOENZIMATICA DE GLICOCONJUGADOS Y GLICOMIMETCOS... 114K€ Cerrado

CTQ2013-44367-C2-1-P DISEÑO RACIONAL Y SINTESIS ESTEREOSELECTIVA DE GLICOMIMETICO... 152K€ Cerrado

PID2020-118893GB-I00 SIMULACION COMPUTACIONAL DE MECANISMOS CATALITICOS EN ENZIMA... 145K€ Cerrado

CTQ2013-44367-C2-2-P ESTUDIO DE LAS INTERACCIONES PROTEINA-CARBOHIDRATOS INVOLUCR... 92K€ Cerrado

Duración del proyecto: 77 meses Fecha Inicio: 2020-12-18
Fecha Fin: 2027-05-31

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 9M€

Descripción del proyecto Enzymes that produce and degrade oligosaccharides and glycoconjugates are present in all kingdoms of life. The ability to visualize, modulate and understand these carbohydrate-active enzymes (CAZymes) therefore offers great potential for human health and sustainable industries. To provide a disruptive shift in our understanding, we adopt in this proposal a multidisciplinary approach combining structural biology, enzymology, computational chemistry, organic synthesis, and chemical biology, with major leaders in these fields part of our CARBOCENTRE Synergy Team. Three fundamental strands will specifically target and ‘capture’ glycoprocessing enzyme active sites. Biochemical and 3-D structural analyses will inform computational dissection of the reaction coordinate of key enzymes for human health and biotechnology processes. Building on our founding work on retaining glycosidases we will also target inverting glycosidases and glycosyltransferases. Following fundamental analyses, our probes will feed research in two major application domains of human health and biotechnology: 1. To provide visualization, diagnosis, and inhibitor assays and clinical lead compounds for enzymes in cancers and genetic diseases (lysosomal storage disorders). 2. To explore the natural diversity of CAZymes and to discover, quantify and optimize new enzymes for food and household applications and for biomass conversion to biofuels. In an iterative cycle, structural biology and enzymology (Davies, York), will inform, through structures of enzymes and enzyme-inhibitor complexes, theoretical and computational chemistry (Rovira, Barcelona), which in turn will guide the design and synthesis (Overkleeft, Leiden), of inhibitors and activity-based probes for ensuing chemical biology studies in the domains of biomedicine and biotechnology.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores