Innovating.works Conecta tu I+D

Mostrando 1 al 20 de 75 resultados

ONCO-SPLICE: Translating Tudor domain splicing inhibitors for oncological applications CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un HORIZON EUROPE: ERC-2024-POC In our effort to characterize metabolic activities in the cell’s nucleus, we discovered that the understudied Tudor domain protein SMNDC1 co...
2024-09-01 - 2026-02-28 | Financiado

ONCO-SPLICE: Translating Tudor domain splicing inhibitors for oncological applications CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un HORIZON EUROPE: ERC-2024-POC In our effort to characterize metabolic activities in the cell’s nucleus, we discovered that the understudied Tudor domain protein SMNDC1 co...
2024-08-01 - 2026-02-28 | Financiado

Rewiring PRC2: Rewiring transcriptional regulation by the PRC2 complex using proximity inducing pharmacology CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un HORIZON EUROPE: HORIZON-MSCA-2023-PF-01 Polycomb repressive complex 2 (PRC2), which incorporates repressive methyl-lysine marks on histone H3 to facilitate global transcriptional r...
2024-04-17 - 2027-06-30 | Financiado

REWIRE: Rewire the lymph node niche to instruct T cell immunity CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un HORIZON EUROPE: ERC-2023-STG Lymph nodes (LN) are communication centers within the lymphatic network that instruct T cell priming and differentiation in homeostasis and...
2023-10-30 - 2028-12-31 | Financiado

T Cell Feedback: T cell regulation by fed state bacterial metabolites CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un HORIZON EUROPE: ERC-2023-STG Intestinal microbial communities expand the functional capabilities of the host via their metabolic attributes. From energy harvest to the p...
2023-09-12 - 2028-12-31 | Financiado

M-Y-cro: Metabolism-YEATS-crosstalk: Elucidating metabolic dependencies of epigenetic YEATS action CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un HORIZON EUROPE: HORIZON-MSCA-2022-PF-01 Metabolism and gene regulations act in concert to shape cellular identity and plasticity. One major line of crosstalk occurs through metabol...
2023-07-12 - 2025-07-31 | Financiado

B-ALLeles: High resolution dissection of non-coding determinants of disease CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH participó en un HORIZON EUROPE: HORIZON-MSCA-2021-PF-01 While mutations at protein-coding sequences have been extensively characterized, the functional role of disease-associated non-coding varian...
2022-08-08 - 2024-10-31 | Financiado

REsolution: Add medical genetic solutions to RESOLUTE REsolution CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un H2020: H2020-JTI-IMI2-2020-22-single-stage Solute carriers (SLCs) are the largest family of membrane transporters encoded in the human genome and their role in trafficking nutrients,...
2021-05-18 - 2023-12-31 | Financiado

TRAP-CART: Tumor targeting through a TME specific regulatory code and programmable CAR T cells CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un H2020: H2020-MSCA-IF-2020 Two major issues hamper successful treatment of solid cancers with CAR T cells. First, immunosuppression imposed by the tumor microenvironme...
2021-03-31 - 2023-03-31 | Financiado

EPI-CART: Understanding and exploiting epigenetic regulation in CAR T cell therapy CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un H2020: ERC-2020-COG The dramatic efficacy of CAR T cell therapy in certain hematopoietic malignancies provides clinical validation of a groundbreaking paradigm:...
2021-03-30 - 2026-11-30 | Financiado

MapInDegraders: Closing the gap studying non obvious ligand induced degradation events CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH tramitó un H2020: H2020-MSCA-IF-2020 Inhibitor-induced target destabilisation has been reported sporadically in recent years. Importantly, despite never actually having been put...
2021-03-13 - 2023-03-31 | Financiado

CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE...