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Metabolism-YEATS-crosstalk: Elucidating metabolic dependencies of epigenetic YEA...

Metabolism-YEATS-crosstalk: Elucidating metabolic dependencies of epigenetic YEATS action Metabolism and gene regulations act in concert to shape cellular identity and plasticity. One major line of crosstalk occurs through metabolites such as acyl-CoAs, which are inscribed on histones as posttranslational modifications... see more

31/07/2025

CEMM FORSCHUNGSZE...

184K€

Project Budget: 184K€

Project leader

CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-07-12

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

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1 Participantes

CEMM FORSCHUNGSZENTRUM FUER...

183.60K€ | Leader

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Project duration: 24 months Date Start: 2023-07-12
End date: 2025-07-31

Project leader

CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 184K€

participation deadline Sin fecha límite de participación.

Project description Metabolism and gene regulations act in concert to shape cellular identity and plasticity. One major line of crosstalk occurs through metabolites such as acyl-CoAs, which are inscribed on histones as posttranslational modifications (PTMs) to be subsequently recognised by reader proteins, resulting in initiation of specific transcriptional programs. The increasing identification of novel PTMs necessitates thorough characterisation, however still remain largely underexplored. For instance, the presence of non-acetyl acyl-Lys PTMs such as crotonylation with YEATS-reader proteins identified to bind these PTMs suggests complex gene regulation programs. However, despite the clinical relevance of YEATS-proteins in various cancers, little is known about their acyl-reading activity and transcriptional consequences. Therefore, this proposal aims to close multiple knowledge gaps regarding overall function and mechanism of the metabolism/acyl-PTM/YEATS communication axis. Considering the metabolic context, I furthermore propose epigenetic YEATS action to be determined by direct interactions with metabolic proteins. Thus, I will first establish an inducible YEATS-degradation platform to characterise the genomic context under various acylate conditions. Next, I will implement a fluorescence-based cell reporter system, which shall reveal putative interactors upon transfection with a CRISPR-KO library targeting metabolic enzymes. Lastly, hits will be biophysically characterized, their metabolic impact within the epigenetic context determined and co-dependencies on relevant cancer cell lines tested. The interdisciplinary approach entailing state-of-the-art chemical and molecular biology tools will be combined with high-throughput screening methods and bioinformatic analyses. Besides elucidating general principles of the metabolism-YEATS epigenetics crosstalk, the results will provide valuable information for novel therapeutic avenues by exploiting identified co-dependencies.

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