Innovating Works

CR-UK

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Showing 1 to 20 of 117 results
TransPot: Translational Research Network in Prostate Cancer CANCER RESEARCH UK LBG participó en un H2020 H2020-MSCA-ITN-2016 The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly...
2016-08-16 - 2021-04-30 | Financiado
NeuroUTR: Systematic investigation of the functional coupling between transcriptional and post transcriptional... CANCER RESEARCH UK LBG participó en un H2020 H2020-MSCA-IF-2014 3' untranslated regions (3' UTRs) serve as a key platform in the RNA regulatory network that controls mRNA translational efficiency, localis...
2015-03-19 - 2017-05-31 | Financiado
SMI REP: Investigating eukaryotic replisome dynamics at the single molecule level CANCER RESEARCH UK LBG participó en un H2020 H2020-MSCA-IF-2014 For cells to reproduce, an accurate duplicate of the genome must be created. This is no small task. The genetic information stored in each c...
2015-03-19 - 2017-09-30 | Financiado
BRCA2Interact: Structural and biochemical characterization of pre recombination complexes CANCER RESEARCH UK LBG participó en un H2020 H2020-MSCA-IF-2014 Homologous recombination (HR) is an essential DNA repair mechanism and defects in different HR factors are linked with disease and cancer pr...
2015-03-17 - 2017-05-31 | Financiado
DC cancer: Development and immunological control of dendritic cell cancer CANCER RESEARCH UK LBG participó en un H2020 H2020-MSCA-IF-2014 Dendritic cells (DC) are powerful antigen-presenting cells that can induce antigen-specific adaptive immunity to pathogens but also protecti...
2015-03-17 - 2017-04-30 | Financiado
QUIC-CONCEPT: QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy CANCER RESEARCH UK LBG participó en un FP6 The QuIC-ConCePT consortium has 2 objectives: 1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proli...
2011-09-01 - 2018-06-30 | Financiado
FUTUGEMET: Functional tumour genomics using metabolomic profiling CANCER RESEARCH UK LBG tramitó un FP7 Metabolite profiling, as demonstrated by the host laboratory, has the power to discriminate single gene alterations and to identify metaboli...
Financiado
CHROMOCOND: A molecular view of chromosome condensation CANCER RESEARCH UK LBG tramitó un FP7 Eukaryotic cells inherit much of their genomic information in the form of chromosomes during cell division. Centimetre-long DNA molecules ar...
Financiado
TGF-BETA AND CANCER: Regulating TGF beta signalling at the transcriptional level and in cancer CANCER RESEARCH UK LBG tramitó un FP7 To understand, treat, cure and ultimately prevent cancer we must first be able to understand the basic mechanisms that regulate normal cell...
Financiado
BCL6-C-JUN-CAX: cooperation between BCL6 and c Jun in lymphoma development and progression CANCER RESEARCH UK LBG tramitó un FP7 Sequential activation of different oncogenes drive the step-wise progression of precancerous cells to highly malignant tumors. A molecular u...
Financiado
PBC-BS: In vivo study of primary B cell responses CANCER RESEARCH UK LBG tramitó un FP7 B cells produce antigen-specific antibodies as part of the adaptive immune response. This is the result of a complex process of activation a...
Financiado
HSCS AND HIF: The role of hypoxia inducible factors in human haematopoietic stem cell biology and leukaemogenesis CANCER RESEARCH UK LBG tramitó un FP7 Mammalian haematopoiesis in the adult takes place predominantly in the bone marrow (BM) where a population of haematopoietic stem cells (HSC...
Financiado
SRF COFACTORS: Cell Biology of SRF cofactors CANCER RESEARCH UK LBG tramitó un FP7 Serum response factor (SRF) regulates the expression of immediate-early genes as well as the expression of many muscle-specific genes. Diffe...
Financiado
RAS AND MMP7: Investigation of a dependency of RAS driven cancers on matrix metalloproteinase 7 CANCER RESEARCH UK LBG tramitó un FP7 Activating point mutations in RAS are present in a large number of tumours. Besides treating tumours by reversing the effects of oncoprotein...
Financiado
ARKADIA AND CANCER: CHARACTERISATION OF ARKADIA FUNCTION IN THE REGULATION OF SNON STABILITY AND ITS ROLE AS A POTENTIAL... CANCER RESEARCH UK LBG tramitó un FP7 Deregulated signalling by transforming growth factor beta (TGF-beta) plays a critical role in tumorigenesis in humans, acting as a tumour su...
Financiado
AAMDDR: DNA damage response and genome stability The role of ATM ATR and the Mre11 complex CANCER RESEARCH UK LBG tramitó un FP7 Chromosomal DNA is continuously subjected to exogenous and endogenous damaging insults. In the presence of DNA damage cells activate a multi...
Financiado
TELOMERES IN MEIOSIS: Telomere function in meiosis CANCER RESEARCH UK LBG tramitó un FP7 Telomeres have long been known to play crucial roles in protecting chromosome ends from attrition and fusion and thus safeguarding genome st...
Financiado
SCOC and FEZ: Functional analysis of SCOC and FEZ proteins in autophagy using mammalian cell models and zebrafish CANCER RESEARCH UK LBG tramitó un FP7 Autophagy is a conserved, highly regulated degradative pathway transferring cytoplasmic components in autophagosomes to lysosomes providing...
Financiado
RETROGRADE TRANSPORT: The role of Rab7 in axonal retrograde transport and human pathologies CANCER RESEARCH UK LBG tramitó un FP7 Neurons are highly polarized cells that depend on anterograde and retrograde transport for survival, differentiation and maintenance of thei...
Financiado
CHROMALC1HCC: The role of ALC1 a novel ATP dependent chromatin remodelling protein in transcriptional regulatio... CANCER RESEARCH UK LBG tramitó un FP7 The genome is continuously exposed to DNA damaging insults that induce a wide variety of lesions. For a proper DNA damage signalling and rep...
Financiado
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