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TransPot: Translational Research Network in Prostate Cancer CANCER RESEARCH UK LBG participó en un H2020: H2020-MSCA-ITN-2016 The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly...
2016-08-16 - 2021-04-30 | Financiado

NeuroUTR: Systematic investigation of the functional coupling between transcriptional and post transcriptional... CANCER RESEARCH UK LBG participó en un H2020: H2020-MSCA-IF-2014 3' untranslated regions (3' UTRs) serve as a key platform in the RNA regulatory network that controls mRNA translational efficiency, localis...
2015-03-19 - 2017-05-31 | Financiado

SMI REP: Investigating eukaryotic replisome dynamics at the single molecule level CANCER RESEARCH UK LBG participó en un H2020: H2020-MSCA-IF-2014 For cells to reproduce, an accurate duplicate of the genome must be created. This is no small task. The genetic information stored in each c...
2015-03-19 - 2017-09-30 | Financiado

BRCA2Interact: Structural and biochemical characterization of pre recombination complexes CANCER RESEARCH UK LBG participó en un H2020: H2020-MSCA-IF-2014 Homologous recombination (HR) is an essential DNA repair mechanism and defects in different HR factors are linked with disease and cancer pr...
2015-03-17 - 2017-05-31 | Financiado

DC cancer: Development and immunological control of dendritic cell cancer CANCER RESEARCH UK LBG participó en un H2020: H2020-MSCA-IF-2014 Dendritic cells (DC) are powerful antigen-presenting cells that can induce antigen-specific adaptive immunity to pathogens but also protecti...
2015-03-17 - 2017-04-30 | Financiado

QUIC-CONCEPT: QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy CANCER RESEARCH UK LBG participó en un FP6: The QuIC-ConCePT consortium has 2 objectives: 1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proli...
2011-09-01 - 2018-06-30 | Financiado

FUTUGEMET: Functional tumour genomics using metabolomic profiling CANCER RESEARCH UK LBG tramitó un FP7: Metabolite profiling, as demonstrated by the host laboratory, has the power to discriminate single gene alterations and to identify metaboli...
Financiado

CHROMOCOND: A molecular view of chromosome condensation CANCER RESEARCH UK LBG tramitó un FP7: Eukaryotic cells inherit much of their genomic information in the form of chromosomes during cell division. Centimetre-long DNA molecules ar...
Financiado

TGF-BETA AND CANCER: Regulating TGF beta signalling at the transcriptional level and in cancer CANCER RESEARCH UK LBG tramitó un FP7: To understand, treat, cure and ultimately prevent cancer we must first be able to understand the basic mechanisms that regulate normal cell...
Financiado

BCL6-C-JUN-CAX: cooperation between BCL6 and c Jun in lymphoma development and progression CANCER RESEARCH UK LBG tramitó un FP7: Sequential activation of different oncogenes drive the step-wise progression of precancerous cells to highly malignant tumors. A molecular u...
Financiado

PBC-BS: In vivo study of primary B cell responses CANCER RESEARCH UK LBG tramitó un FP7: B cells produce antigen-specific antibodies as part of the adaptive immune response. This is the result of a complex process of activation a...
Financiado

HSCS AND HIF: The role of hypoxia inducible factors in human haematopoietic stem cell biology and leukaemogenesis CANCER RESEARCH UK LBG tramitó un FP7: Mammalian haematopoiesis in the adult takes place predominantly in the bone marrow (BM) where a population of haematopoietic stem cells (HSC...
Financiado

SRF COFACTORS: Cell Biology of SRF cofactors CANCER RESEARCH UK LBG tramitó un FP7: Serum response factor (SRF) regulates the expression of immediate-early genes as well as the expression of many muscle-specific genes. Diffe...
Financiado

RAS AND MMP7: Investigation of a dependency of RAS driven cancers on matrix metalloproteinase 7 CANCER RESEARCH UK LBG tramitó un FP7: Activating point mutations in RAS are present in a large number of tumours. Besides treating tumours by reversing the effects of oncoprotein...
Financiado

ARKADIA AND CANCER: CHARACTERISATION OF ARKADIA FUNCTION IN THE REGULATION OF SNON STABILITY AND ITS ROLE AS A POTENTIAL... CANCER RESEARCH UK LBG tramitó un FP7: Deregulated signalling by transforming growth factor beta (TGF-beta) plays a critical role in tumorigenesis in humans, acting as a tumour su...
Financiado

AAMDDR: DNA damage response and genome stability The role of ATM ATR and the Mre11 complex CANCER RESEARCH UK LBG tramitó un FP7: Chromosomal DNA is continuously subjected to exogenous and endogenous damaging insults. In the presence of DNA damage cells activate a multi...
Financiado

TELOMERES IN MEIOSIS: Telomere function in meiosis CANCER RESEARCH UK LBG tramitó un FP7: Telomeres have long been known to play crucial roles in protecting chromosome ends from attrition and fusion and thus safeguarding genome st...
Financiado

SCOC and FEZ: Functional analysis of SCOC and FEZ proteins in autophagy using mammalian cell models and zebrafish CANCER RESEARCH UK LBG tramitó un FP7: Autophagy is a conserved, highly regulated degradative pathway transferring cytoplasmic components in autophagosomes to lysosomes providing...
Financiado

RETROGRADE TRANSPORT: The role of Rab7 in axonal retrograde transport and human pathologies CANCER RESEARCH UK LBG tramitó un FP7: Neurons are highly polarized cells that depend on anterograde and retrograde transport for survival, differentiation and maintenance of thei...
Financiado

CHROMALC1HCC: The role of ALC1 a novel ATP dependent chromatin remodelling protein in transcriptional regulatio... CANCER RESEARCH UK LBG tramitó un FP7: The genome is continuously exposed to DNA damaging insults that induce a wide variety of lesions. For a proper DNA damage signalling and rep...
Financiado

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