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IMI2-2016-10-06
IMI2-2016-10-06: Unlocking the Solute Carrier Gene-Family for Effective New Therapies (Unlock SLCs)
Specific Challenge:The healthy functioning of living cells requires strict control over the import and export of ions, metabolites and nutrients across membranes. Highly regulated transport proteins fulfil this role, and it has been estimated that ~10% of the human genome is linked to membrane transport. The solute carrier (SLC) family is the largest class of such proteins (~400 members), and SLCs play vital roles across practically all cell types in all tissues. The importance of SLCs in disease can be illustrated by human genetic data which suggest that roughly 50% of SLCs are associated with a human disease-related phenotype compared to a rate of only ~20% for the broader human genome. A significant barrier to the study of SLCs is gaining access to relevant reagents and cell systems in which they are expressed
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Europeo
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Specific Challenge:The healthy functioning of living cells requires strict control over the import and export of ions, metabolites and nutrients across membranes. Highly regulated transport proteins fulfil this role, and it has been estimated that ~10% of the human genome is linked to membrane transport. The solute carrier (SLC) family is the largest class of such proteins (~400 members), and SLCs play vital roles across practically all cell types in all tissues. The importance of SLCs in disease can be illustrated by human genetic data which suggest that roughly 50% of SLCs are associated with a human disease-related phenotype compared to a rate of only ~20% for the broader human genome. A significant barrier to the study of SLCs is gaining access to relevant reagents and cell systems in which they are expressed

If these reagents become available it will lead to an acceleration in the discovery of effective new medicines for patients suffering from a range of diseases, to the benefit of society at large


Scope:This topic aims to unlock the therapeutic potential within the SLC gene family by overcoming many of the technical barriers that have hindere... ver más

Specific Challenge:The healthy functioning of living cells requires strict control over the import and export of ions, metabolites and nutrients across membranes. Highly regulated transport proteins fulfil this role, and it has been estimated that ~10% of the human genome is linked to membrane transport. The solute carrier (SLC) family is the largest class of such proteins (~400 members), and SLCs play vital roles across practically all cell types in all tissues. The importance of SLCs in disease can be illustrated by human genetic data which suggest that roughly 50% of SLCs are associated with a human disease-related phenotype compared to a rate of only ~20% for the broader human genome. A significant barrier to the study of SLCs is gaining access to relevant reagents and cell systems in which they are expressed

If these reagents become available it will lead to an acceleration in the discovery of effective new medicines for patients suffering from a range of diseases, to the benefit of society at large


Scope:This topic aims to unlock the therapeutic potential within the SLC gene family by overcoming many of the technical barriers that have hindered their study and prevented their exploitation as drug targets by generating research tools and by making them freely available to the scientific community.


Expected Impact: New open access research tools, techniques, reagents, and knowledge to the biomedical research community that will rapidly accelerate the pace of research in the field of SLCs. These advances are expected to impact both basic research and drug discovery alike. The discovery of new drug targets. Since SLCs are expressed in practically all cell types across all tissues, their therapeutic potential spans many disease areas, including, oncology, immunology, neurosciences, metabolism and cardiovascular diseases. This project will benefit patients and society through the accelerated discovery of new drugs targeting SLCs which will provide effective therapies for broad range of diseases..
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Temáticas Obligatorias del proyecto: Temática principal:

Características del consorcio

Ámbito Europeo : La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Tipo y tamaño de organizaciones: El diseño de consorcio necesario para la tramitación de esta ayuda necesita de:

Características del Proyecto

Requisitos de diseño: Duración:
Requisitos técnicos: Specific Challenge:The healthy functioning of living cells requires strict control over the import and export of ions, metabolites and nutrients across membranes. Highly regulated transport proteins fulfil this role, and it has been estimated that ~10% of the human genome is linked to membrane transport. The solute carrier (SLC) family is the largest class of such proteins (~400 members), and SLCs play vital roles across practically all cell types in all tissues. The importance of SLCs in disease can be illustrated by human genetic data which suggest that roughly 50% of SLCs are associated with a human disease-related phenotype compared to a rate of only ~20% for the broader human genome. A significant barrier to the study of SLCs is gaining access to relevant reagents and cell systems in which they are expressed Specific Challenge:The healthy functioning of living cells requires strict control over the import and export of ions, metabolites and nutrients across membranes. Highly regulated transport proteins fulfil this role, and it has been estimated that ~10% of the human genome is linked to membrane transport. The solute carrier (SLC) family is the largest class of such proteins (~400 members), and SLCs play vital roles across practically all cell types in all tissues. The importance of SLCs in disease can be illustrated by human genetic data which suggest that roughly 50% of SLCs are associated with a human disease-related phenotype compared to a rate of only ~20% for the broader human genome. A significant barrier to the study of SLCs is gaining access to relevant reagents and cell systems in which they are expressed
¿Quieres ejemplos? Puedes consultar aquí los últimos proyectos conocidos financiados por esta línea, sus tecnologías, sus presupuestos y sus compañías.
Capítulos financiables: Los capítulos de gastos financiables para esta línea son:
Personnel costs.
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Purchase costs.
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
Subcontracting costs.
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Amortizaciones.
Activos.
Otros Gastos.
Madurez tecnológica: La tramitación de esta ayuda requiere de un nivel tecnológico mínimo en el proyecto de TRL 5:. Los elementos básicos de la innovación son integrados de manera que la configuración final es similar a su aplicación final, es decir que está listo para ser usado en la simulación de un entorno real. Se mejoran los modelos tanto técnicos como económicos del diseño inicial, se ha identificado adicionalmente aspectos de seguridad, limitaciones ambiéntales y/o regulatorios entre otros. + info.
TRL esperado:

Características de la financiación

Intensidad de la ayuda: Sólo fondo perdido + info
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Please read carefully all provisions below before the preparation of your application.
You can access the description of the different topics in the Call 10 topics text.
The budget breakdown for this Call is given at the end of the Call topics text, in the Conditions for this Call for proposals section, as well as the following information :
List of countries and applicable rules for funding
 
Eligibility and admissibility conditions
 
Evaluation criteria and procedure, scoring and treshold:  described in the IMI2 Manual for evaluation, submission and grant award.
 
Indicative timetable for evaluation and grant agreement
 
Provisions, proposal templates and evaluation forms for the type of actions under the Call topics:
IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):
Summary of the most relevant provisions for participating in IMI2 actions
Proposal templates are available after entering the submission tool
Standard evaluation form
IMI2 Model Grant Agreement
Template for essential clinical trials information
 
Please read carefully all provisions below before the preparation of your application.
You can access the description of the different topics in the Call 10 topics text.
The budget breakdown for this Call is given at the end of the Call topics text, in the Conditions for this Call for proposals section, as well as the following information :
List of countries and applicable rules for funding
 
Eligibility and admissibility conditions
 
Evaluation criteria and procedure, scoring and treshold:  described in the IMI2 Manual for evaluation, submission and grant award.
 
Indicative timetable for evaluation and grant agreement
 
Provisions, proposal templates and evaluation forms for the type of actions under the Call topics:
IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):
Summary of the most relevant provisions for participating in IMI2 actions
Proposal templates are available after entering the submission tool
Standard evaluation form
IMI2 Model Grant Agreement
Template for essential clinical trials information
 
Garantías:
No exige Garantías
No existen condiciones financieras para el beneficiario.

Información adicional de la convocatoria

Efecto incentivador: Esta ayuda tiene efecto incentivador, por lo que el proyecto no puede haberse iniciado antes de la presentación de la solicitud de ayuda. + info.
Respuesta Organismo: Se calcula que aproximadamente, la respuesta del organismo una vez tramitada la ayuda es de:
Meses de respuesta:
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