HORIZON EUROPE
Europeo
Scope:Specific challenge
Rapid detection of Ebola infections in the field or at decentralised healthcare centers is an urgent need in the current crisis of the outbreak of EVD and will remain important even after the current crisis may have subsided. Additional technologies addressing various healthcare facilities settings will also be important to maintain surveillance in the long term. Current PCR-based tests have a number of limitations related to time and procedures requiring infrastructures and specific training. Tools and technologies are needed to provide quality diagnostics at low cost. Several such tests are already under development but their performance and practicability are unknown.
Scope
The project(s) will work on developing rapid diagnostics to detect EVD at acceptable costs and with very high sensitivity and specificity. At a minimum a rapid diagnostic test should be able to be deployed at decentralised health care facilities under conditions with minimum laboratory infrastructures available. Projects can work on validating existing tests or on expanding the use of tools currently being developed, through clinical validatio...
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Scope:Specific challenge
Rapid detection of Ebola infections in the field or at decentralised healthcare centers is an urgent need in the current crisis of the outbreak of EVD and will remain important even after the current crisis may have subsided. Additional technologies addressing various healthcare facilities settings will also be important to maintain surveillance in the long term. Current PCR-based tests have a number of limitations related to time and procedures requiring infrastructures and specific training. Tools and technologies are needed to provide quality diagnostics at low cost. Several such tests are already under development but their performance and practicability are unknown.
Scope
The project(s) will work on developing rapid diagnostics to detect EVD at acceptable costs and with very high sensitivity and specificity. At a minimum a rapid diagnostic test should be able to be deployed at decentralised health care facilities under conditions with minimum laboratory infrastructures available. Projects can work on validating existing tests or on expanding the use of tools currently being developed, through clinical validation to registration and launch. Projects must in any case include a phase of clinical validation in the field under real-world conditions, address manufacturing and access path to ensure sustainable distribution including taking into account ethical considerations and the health systems context. Any suitable technology can be used but the focus should be on practical solutions that meet the following criteria:
- Very high sensitivity and specificity
- Ability to be deployed in resource-limited settings
- Minimal training required to operate
- Capability of multiplexing in order to include different ebola strains
- Time to result 15-30 minutes (desirable) – 3 hours (acceptable)
- Sample type for intake: blood (capillary fingerstick desirable), other less invasive sample types (urine, etc.)
Additional capabilities to provide epidemiological monitoring (eg. Internet connectivity) would be valuable.
It is considered that an IMI2 JU financial contribution of approximately 7.5 million and an EFPIA in-kind contribution of approximately EUR 7.5 million would allow this specific challenge to be addressed appropriately. Nevertheless, this does not preclude submission and selection of proposals requesting other amounts.
Expected impact
Increased availability of rapid diagnostic tests for EVD, providing in a first step immediate impact on public health in regions where the disease is endemic.
Possible impact on business opportunities for European SMEs active in this area.
Cross-cutting Priorities:International cooperation
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Características del consorcio
:
La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Características del Proyecto
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Características de la financiación
Please note that submitting proposals for this call can only be done through theIMI SOFIA software tool.
Please read carefully all provisions below before the preparation of your application.
List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
Eligibility and admissibility conditions: described in the IMI2 Manual for evaluation, submission and grant award. See also the Commission Delegated Regulation (EU) N° 622/2014 of 14 February 2014
Evaluation
For a guide to the submission and evaluation process including evaluation criteria and procedure, scoring and threshold: please see the IMI2 Manual for submission, evaluation and grant award
See also the IMI2 RIA Proposal Template and IMI2 RIA Evaluation Form in section 6, below.
Proposal page limits and layout: Please refer to IMI2 RIA Proposal Template in section 6, below.
Indicative timetable for evaluation and grant agreement:
Information on the outcome of one-stage evaluation: maximum 2 months from the final date for submission.
Signature of grant agreements: maximum 1 month from the date of informing successful applicants.
Provisions, proposal templates and evaluation forms for the type(s) of action(s) under... Please read the IMI2 2nd Call Topic Text for full details of this topic.
Please note that submitting proposals for this call can only be done through theIMI SOFIA software tool.
Please read carefully all provisions below before the preparation of your application.
List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
Eligibility and admissibility conditions: described in the IMI2 Manual for evaluation, submission and grant award. See also the Commission Delegated Regulation (EU) N° 622/2014 of 14 February 2014
Evaluation
For a guide to the submission and evaluation process including evaluation criteria and procedure, scoring and threshold: please see the IMI2 Manual for submission, evaluation and grant award
See also the IMI2 RIA Proposal Template and IMI2 RIA Evaluation Form in section 6, below.
Proposal page limits and layout: Please refer to IMI2 RIA Proposal Template in section 6, below.
Indicative timetable for evaluation and grant agreement:
Information on the outcome of one-stage evaluation: maximum 2 months from the final date for submission.
Signature of grant agreements: maximum 1 month from the date of informing successful applicants.
Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:
Summary of the most relevant provisions for participating in IMI2 actions
IMI2 RIA Proposal Template
IMI2 RIA Evaluation Form
IMI2 Model Grant Agreement
Información adicional de la convocatoria
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