HORIZON EUROPE
Europeo
Specific Challenge:Plant Molecular Factory is defined here as the use of plants or plant cells to produce high-value products such as proteins, peptides and bioactive secondary metabolites, particularly for pharmaceutical and medical/veterinary, diagnostic, agricultural and industrial applications, including strategies to engineer plants to allow better processing of biomass into such high-value products. The specific challenge consists in increasing the availability to end users, lowering the cost of end products by scaling-up efficient manufacturing and purification process (e.g. high expression yields, the recombinant product authenticity), shortening production cycles for necessary efficacy and achieving high product yield. For the successful implementation market related issues such as regulatory compliance and approval, public acceptance and engagement need to be fully addressed.
Scope:Project(s) under this topic should be industry driven and focus on the demonstration of innovative technologies for molecular farming approaches. Higher and lower plants or plant cells, or algae can be considered. Bottlenecks such as the optimization of gene expression, use...
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Specific Challenge:Plant Molecular Factory is defined here as the use of plants or plant cells to produce high-value products such as proteins, peptides and bioactive secondary metabolites, particularly for pharmaceutical and medical/veterinary, diagnostic, agricultural and industrial applications, including strategies to engineer plants to allow better processing of biomass into such high-value products. The specific challenge consists in increasing the availability to end users, lowering the cost of end products by scaling-up efficient manufacturing and purification process (e.g. high expression yields, the recombinant product authenticity), shortening production cycles for necessary efficacy and achieving high product yield. For the successful implementation market related issues such as regulatory compliance and approval, public acceptance and engagement need to be fully addressed.
Scope:Project(s) under this topic should be industry driven and focus on the demonstration of innovative technologies for molecular farming approaches. Higher and lower plants or plant cells, or algae can be considered. Bottlenecks such as the optimization of gene expression, use of proper cell lines, and maximizing efficiency of downstream product purification may be considered. Project(s) could also encompass issues related to protein stability and degradation and/or improvements of bioreactor/containment design, and culture parameters. Furthermore, the authenticity challenge may be addressed. The techno-economic viability of the proposed concepts, the overall economic and environmental sustainability issues should also be critical elements and confirmed by LCA. To address properly regulatory compliance and approval and public acceptance issues, involvement and consultation with appropriate regulatory bodies and consumer and civil society groups (NGOs, end-user organisations etc) are necessary. This will create an efficient and cost-effective alternative methodology for the production of high value end-products. A strong participation of industry/SMEs should help contribute to the realization of the expected outcomes.
The Commission considers that proposals requesting a contribution from the EU of an indicative amount of EUR 9 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.
Expected Impact:The project(s) shall contribute to the objective of improved competitiveness of European bioindustry, and be of benefit to users by allowing development of end-products with superior safety and economic parameters. This will be achieved by upgrading plant-based protein production platforms to the level of currently used and more advanced microbial or animal cell systems, opening thus full range of additional benefits arising from plant based production (scalability, absence of shared pathogens etc).
It is expected that action funded under this topic will advance the opportunity shown at research scale into demonstration scale, to allow the technology to become mature and fully economically competitive. This will be achieved by focusing on end-products with high value, by ensuring early industrial engagement and by addressing pertinent regulatory and public acceptance issues. The Technology Readiness Levels covered by the projects could range from 4 to 7.
It is expected that this action will create new opportunities for European bioindustries by increasing the application of bioactive molecules for the end product development and that it will allow an effective integration of research community, agriculture, bioprocessing industry and end-user representative groups.
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Características del consorcio
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La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Características del Proyecto
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Características de la financiación
List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
Note also that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects. See the information in the Online Manual.
Eligibility and admissibility conditions: described in part B and C of the General Annexes of the General Work Programme.
Proposal page limits and layout: Please refer to Part B of the standard proposal template.
Evaluation
3.1 Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme.
3.2 Submission and evaluation process: Guide to the submission and evaluation process
Indicative timetable for evaluation and grant agreement:
Information on the outcome of single-stage evaluation: maximum 5 months from the deadline for submission.
Signature of grant agreements: maximum 8 months from the deadline for submission.
Information on the outcome of two-stage evaluation:
For stage 1: maximum 3 months from the deadline for submission.
&am... Please read carefully all provisions below before the preparation of your application.
List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
Note also that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects. See the information in the Online Manual.
Eligibility and admissibility conditions: described in part B and C of the General Annexes of the General Work Programme.
Proposal page limits and layout: Please refer to Part B of the standard proposal template.
Evaluation
3.1 Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme.
3.2 Submission and evaluation process: Guide to the submission and evaluation process
Indicative timetable for evaluation and grant agreement:
Information on the outcome of single-stage evaluation: maximum 5 months from the deadline for submission.
Signature of grant agreements: maximum 8 months from the deadline for submission.
Information on the outcome of two-stage evaluation:
For stage 1: maximum 3 months from the deadline for submission.
For stage 2: maximum 5 months from the deadline for submission.
Signature of grant agreements: maximum 8 months from the deadline for submission.
Additional provisions:
Horizon 2020 budget flexibility
Classified information
Technology readiness levels (TRL) – where a topic description refers to TRL, these definitions apply.
Financial support to Third Parties – where a topic description foresees financial support to Third Parties, these provisions apply.
Open access must be granted to all scientific publications resulting from Horizon 2020 actions.
Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.
Open access to research data
The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in annex L of the Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.
Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.
Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.
Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs.
Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.
The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement.
Further information on the Open Research Data Pilot is made available in the H2020 Online Manual.
Additional documents:
H2020 Work Programme 2016-17: Introduction
H2020 Work Programme 2016-17: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
H2020 Work Programme 2016-17: Dissemination, Exploitation and Evaluation
H2020 Work Programme 2016-17: General Annexes
Euratom Work Programme 2016-17
Legal basis: Horizon 2020 - Regulation of Establishment
Legal basis: Horizon 2020 Rules for Participation
Legal basis: Horizon 2020 Specific Programme
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