HORIZON EUROPE
Europeo
Specific Challenge:Neuropathic pain (NP) is a widespread disease affecting 6-8% of the population, causing great misery, and incurring huge costs to society. Current therapies are inadequate, addressing only the symptoms not the causes of the pain. In fact, the aetiologies of the disease are poorly understood, hindering the development of new analgesics with improved efficacies.
This topic proposes to study the interactions between hiPS cell derived neurons and glia to guide the discovery of effective analgesics and of clinically useful biomarkers, and help improve the health care of millions of patients.
For more information, please see the IMI2 Call 7 topic text.
Scope:The Neuropathic Pain project will:
Develop in vitro cell cultures which reflect the interactions between neurons and glia in healthy neuronal tissues Use HCS technology to perform fast multiparametric screening of many conditions. Analyse the intra- and intercellular signalling pathways in samples of rat tissue Collect enough information to permit the definition of interventions which at least alleviate NP better than current treatments For more inform...
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Specific Challenge:Neuropathic pain (NP) is a widespread disease affecting 6-8% of the population, causing great misery, and incurring huge costs to society. Current therapies are inadequate, addressing only the symptoms not the causes of the pain. In fact, the aetiologies of the disease are poorly understood, hindering the development of new analgesics with improved efficacies.
This topic proposes to study the interactions between hiPS cell derived neurons and glia to guide the discovery of effective analgesics and of clinically useful biomarkers, and help improve the health care of millions of patients.
For more information, please see the IMI2 Call 7 topic text.
Scope:The Neuropathic Pain project will:
Develop in vitro cell cultures which reflect the interactions between neurons and glia in healthy neuronal tissues Use HCS technology to perform fast multiparametric screening of many conditions. Analyse the intra- and intercellular signalling pathways in samples of rat tissue Collect enough information to permit the definition of interventions which at least alleviate NP better than current treatments For more information, please see the IMI2 Call 7 topic text.
Expected Impact:Deepen the understanding of clinical NP at the cellular and genetic levels.
In vitro assays will be developed to improve methods for investigating
Greatly improve the chances of identifying and developing curative analgesic therapies for chronic NP which would enhance the quality of life for millions of patients, and bring substantial cost savings in healthcare.
For more information, please see the IMI2 Call 7 topic text.
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Características del consorcio
:
La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Características del Proyecto
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Características de la financiación
You can access the description of the different topics in the Call topics text.
The budget breakdown for this Call is given at the end of the Call topics text, in the Call Conditions section (page 78), as well as the following information :
List of countries and applicable rules for funding
Eligibility and admissibility conditions
Evaluation criteria and procedure, scoring and threshold : described in the IMI Manual for Submission, Evaluation and Grant award
Indicative timetable for evaluation and grant agreement
Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:
IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):
Summary of the most relevant provisions for participating in IMI2 actions
Standard proposal template
Standard evaluation form
IMI2 Model Grant Agreement
Template for Essential Clinical Trials Information
MI2 Coordination and Support Action (IMI2-CSA):
Summary of the most relevant provisions for participating in IMI2 actions
Standard proposal template
Standard evaluation form
IMI2 Model Grant Agreement
Template for Essential Clinical Trials Information
Please read carefully all provisions below before the preparation of your application.
You can access the description of the different topics in the Call topics text.
The budget breakdown for this Call is given at the end of the Call topics text, in the Call Conditions section (page 78), as well as the following information :
List of countries and applicable rules for funding
Eligibility and admissibility conditions
Evaluation criteria and procedure, scoring and threshold : described in the IMI Manual for Submission, Evaluation and Grant award
Indicative timetable for evaluation and grant agreement
Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:
IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):
Summary of the most relevant provisions for participating in IMI2 actions
Standard proposal template
Standard evaluation form
IMI2 Model Grant Agreement
Template for Essential Clinical Trials Information
MI2 Coordination and Support Action (IMI2-CSA):
Summary of the most relevant provisions for participating in IMI2 actions
Standard proposal template
Standard evaluation form
IMI2 Model Grant Agreement
Template for Essential Clinical Trials Information
Información adicional de la convocatoria
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