HORIZON EUROPE
Europeo
Specific Challenge:Integration and application of metagenomics data from the human microbiome has shown large potential for personalised medicine approaches, although causal relationships and confounders are still largely unknown. Comparable information and details about microbiome composition and functionality in healthy citizen and patients are very valuable to complete the picture i.e. to better understand the healthy microbiome and to predict its development.
The number of European and international projects and initiatives is increasing but their results and data cannot be properly compared as they have different underlying methods, standards and operating procedures. The International Human Microbiome Consortium (IHMC) as well as other current initiatives aim to strengthen international cooperation, to increase data comparability and to agree common standards, procedures and methods. There is a need to avoid having the same research carried out multiple times at different places and to better agree at European and at international level. This collaboration should increase coherence and data comparability to better exploit existing microbiome data and clinical inf...
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Specific Challenge:Integration and application of metagenomics data from the human microbiome has shown large potential for personalised medicine approaches, although causal relationships and confounders are still largely unknown. Comparable information and details about microbiome composition and functionality in healthy citizen and patients are very valuable to complete the picture i.e. to better understand the healthy microbiome and to predict its development.
The number of European and international projects and initiatives is increasing but their results and data cannot be properly compared as they have different underlying methods, standards and operating procedures. The International Human Microbiome Consortium (IHMC) as well as other current initiatives aim to strengthen international cooperation, to increase data comparability and to agree common standards, procedures and methods. There is a need to avoid having the same research carried out multiple times at different places and to better agree at European and at international level. This collaboration should increase coherence and data comparability to better exploit existing microbiome data and clinical information in a standardised way.
Scope:Proposals should aim for synergistic collaboration and agreement across various research and innovation programmes on the human microbiome, in Europe and worldwide, dealing with sample collection, processing, standardisation and healthy states references at different sites of the human body (not only one organ), including also interaction with omics, impact of drugs, nutritional and environmental aspects as well as sex and gender differences. In particular, they should support the agreement of concrete references of healthy human metagenomes across various different populations. Proposals should map the progress and the state of play for specific disease and health issues as well as the success and meaningfulness in different countries. They should propose concrete and strategic research actions on the human microbiome addressing gaps, emerging fields and political priorities. They should complement, support and enhance cooperation in similar activities within Europe and beyond[1]. In line with the strategy for EU international cooperation in research and innovation (COM(2012)497), international cooperation is encouraged with relevant partners from outside the EU. Proposals should cover the whole spectrum of human microbiome research from patient data collection all the way to study reporting in publications, social, ethical and legal aspects. Proposals should avoid networking without output and provide appropriate indicators to measure its progress and impact.
The Commission considers that proposals requesting a contribution from the EU between EUR 1.5 and EUR 2 Million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.
Expected Impact:International agreement on concrete methods, standards, procedures and in vivo models. Harmonisation and increased comparability of metagenomics, metabolomics and human microbiome data in Europe and beyond.International agreement on definitive references of healthy human metagenomes. These references should apply across various different populations and allow end-users and citizens to see which microbiome is clinically healthy.More meaningful results through collaborative synergistic collection of microbiome data from different directions. Improved coherence and reduction of overlap between national, EU and other funding in the area of human microbiome research, thus ensuring an efficient use of the available human and financial resources.Knowledge exchange and enhanced engagement of citizens, scientists and political stakeholders for priority health risks. Validated results will be delivered faster to people.Integration of metagenomics and human microbiome references into other multilateral co-operation areas or personalised medicine approaches.
Cross-cutting Priorities:Open InnovationOpen ScienceInternational cooperationGender
[1]Proposals should take into account other relevant European and international research and networking initiatives as well as “one health initiatives”.
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Características del consorcio
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La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Características del Proyecto
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Características de la financiación
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects. See the information in the Online Manual.
In recognition of the opening of the US National Institutes of Health’s programmes to European researchers, any legal entity established in the United States of America is eligible to receive Union funding to support its participation in projects supported under this topic.
2. Eligibility and admissibility conditions: described in Annex B and Annex C of the Work Programme.
Proposal page limits and layout: please refer to Part B of the proposal template in the submission system below.
3. Evaluation:
Evaluation criteria, scoring and thresholds are described in Annex H of the Work Programme.
Submission and evaluation processes are described in the Online Manual.
The thresholds for each criterion in a single stage process will be 4 (Excellence), 4 (Impact) and 3 (Implementation). The cumulative threshold will be 12.
4. Indicative time for evaluation and grant agreements:
Information on the outcome of evaluation (single-stage call): maximum 5 months from the deadline for submission.
Signature of grant agreements: maximum 8 months from the deadline for submi... 1. Eligible countries: described in Annex A of the Work Programme.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects. See the information in the Online Manual.
In recognition of the opening of the US National Institutes of Health’s programmes to European researchers, any legal entity established in the United States of America is eligible to receive Union funding to support its participation in projects supported under this topic.
2. Eligibility and admissibility conditions: described in Annex B and Annex C of the Work Programme.
Proposal page limits and layout: please refer to Part B of the proposal template in the submission system below.
3. Evaluation:
Evaluation criteria, scoring and thresholds are described in Annex H of the Work Programme.
Submission and evaluation processes are described in the Online Manual.
The thresholds for each criterion in a single stage process will be 4 (Excellence), 4 (Impact) and 3 (Implementation). The cumulative threshold will be 12.
4. Indicative time for evaluation and grant agreements:
Information on the outcome of evaluation (single-stage call): maximum 5 months from the deadline for submission.
Signature of grant agreements: maximum 8 months from the deadline for submission.
5. Proposal templates, evaluation forms and model grant agreements (MGA):
Coordination and Support Action:
Specific provisions and funding rates
Standard proposal template
Standard evaluation form
General MGA - Multi-Beneficiary
Annotated Grant Agreement
Essential information for clinical studies
6. Additional provisions:
Horizon 2020 budget flexibility
Classified information
Technology readiness levels (TRL) – where a topic description refers to TRL, these definitions apply.
Members of consortium are required to conclude a consortium agreement, in principle prior to the signature of the grant agreement.
8. Additional documents:
Introduction WP 2018-20
Health, demographic change and well-being WP 2018-20
General annexes to the Work Programme 2018-2020
Legal basis: Horizon 2020 Regulation of Establishment
Legal basis: Horizon 2020 Rules for Participation
Legal basis: Horizon 2020 Specific Programme
7. Open access must be granted to all scientific publications resulting from Horizon 2020 actions.
Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.
Open access to research data
The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in Annex L of the Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.
Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.
Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.
Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs. See the Online Manual.
Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.
The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement.
Información adicional de la convocatoria
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