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IMI2-2016-09-01
IMI2-2016-09-01: ADDRESSING THE CLINICAL BURDEN OF CLOSTRIDIUM DIFFICILE INFECTION (CDI): EVALUATION OF THE BURDEN, CURRENT PRACTICES AND SET-UP OF A EUROPEAN RESEARCH PLATFORM (PART OF THE IMI NEW DRUGS FOR
Specific Challenge:Infection with Clostridium difficile, a Gram-positive spore-forming anaerobe, is the most common cause of nosocomial diarrhoea in developed countries and leads to symptoms that range from self-limiting mild-moderate watery diarrhea to severe fulminant diarrhea, abdominal pain and pseudomembranous colitis. In some patients it may progress to toxic megacolon, colonic perforation and death.
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Europeo
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Presentación: Consorcio Consorcio: Esta ayuda está diseñada para aplicar a ella en formato consorcio.
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Esta ayuda financia Proyectos: Objetivo del proyecto:

Specific Challenge:Infection with Clostridium difficile, a Gram-positive spore-forming anaerobe, is the most common cause of nosocomial diarrhoea in developed countries and leads to symptoms that range from self-limiting mild-moderate watery diarrhea to severe fulminant diarrhea, abdominal pain and pseudomembranous colitis. In some patients it may progress to toxic megacolon, colonic perforation and death.

Over 500,000 new cases of C. difficile infection occur each year in the US and estimates suggest greater than 400,000 diagnosed CDI events occur annually in Europe, although the true incidence is likely to be much higher. Furthermore, the burden of CDI outside of the acute care hospital environment, particularly in nursing homes and long-term care facilities, is under-estimated.

There is therefore a need to develop a robust assessment of the burden of CDI and current practices in Europe.


Scope:Development of a detailed understanding of the epidemiology and clinical impact of CDI; more specifically to:

align and understand the unmet public health needs relating to CDI; identify the direct and long term burden on health... ver más

Specific Challenge:Infection with Clostridium difficile, a Gram-positive spore-forming anaerobe, is the most common cause of nosocomial diarrhoea in developed countries and leads to symptoms that range from self-limiting mild-moderate watery diarrhea to severe fulminant diarrhea, abdominal pain and pseudomembranous colitis. In some patients it may progress to toxic megacolon, colonic perforation and death.

Over 500,000 new cases of C. difficile infection occur each year in the US and estimates suggest greater than 400,000 diagnosed CDI events occur annually in Europe, although the true incidence is likely to be much higher. Furthermore, the burden of CDI outside of the acute care hospital environment, particularly in nursing homes and long-term care facilities, is under-estimated.

There is therefore a need to develop a robust assessment of the burden of CDI and current practices in Europe.


Scope:Development of a detailed understanding of the epidemiology and clinical impact of CDI; more specifically to:

align and understand the unmet public health needs relating to CDI; identify the direct and long term burden on healthcare systems; set up a EU research platform that will provide support for potential proof of concept studies of new prevention and treatment strategies.
Expected Impact:These efforts can be expected to result in the support of adequate public health intervention and practices. It will help in speeding up the development of alternative prevention and treatment approaches.


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Temáticas Obligatorias del proyecto: Temática principal: Bacteria Public health and epidemiology Gram-positive

Características del consorcio

Ámbito Europeo : La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Tipo y tamaño de organizaciones: El diseño de consorcio necesario para la tramitación de esta ayuda necesita de:

Características del Proyecto

Requisitos de diseño: Duración:
Requisitos técnicos: Specific Challenge:Infection with Clostridium difficile, a Gram-positive spore-forming anaerobe, is the most common cause of nosocomial diarrhoea in developed countries and leads to symptoms that range from self-limiting mild-moderate watery diarrhea to severe fulminant diarrhea, abdominal pain and pseudomembranous colitis. In some patients it may progress to toxic megacolon, colonic perforation and death. Specific Challenge:Infection with Clostridium difficile, a Gram-positive spore-forming anaerobe, is the most common cause of nosocomial diarrhoea in developed countries and leads to symptoms that range from self-limiting mild-moderate watery diarrhea to severe fulminant diarrhea, abdominal pain and pseudomembranous colitis. In some patients it may progress to toxic megacolon, colonic perforation and death.
¿Quieres ejemplos? Puedes consultar aquí los últimos proyectos conocidos financiados por esta línea, sus tecnologías, sus presupuestos y sus compañías.
Capítulos financiables: Los capítulos de gastos financiables para esta línea son:
Personnel costs.
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Purchase costs.
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
Subcontracting costs.
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Madurez tecnológica: La tramitación de esta ayuda requiere de un nivel tecnológico mínimo en el proyecto de TRL 5:. Los elementos básicos de la innovación son integrados de manera que la configuración final es similar a su aplicación final, es decir que está listo para ser usado en la simulación de un entorno real. Se mejoran los modelos tanto técnicos como económicos del diseño inicial, se ha identificado adicionalmente aspectos de seguridad, limitaciones ambiéntales y/o regulatorios entre otros. + info.
TRL esperado:

Características de la financiación

Intensidad de la ayuda: Sólo fondo perdido + info
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Please read carefully all provisions below before the preparation of your application !
You can access the description of the different topics in the IMI2 Call 9 topics text 
The budget breakdown for this Call is given at the end of the Call topics text, in the Call Conditions section (starting page 61), as well as the following information :
List of countries and applicable rules for funding
 
Eligibility and admissibility conditions
Evaluation criteria and procedure, scoring and threshold: described in the Manual for submission, evaluation and grant award      
 
Indicative timetable for evaluation and grant agreement
Provisions, proposal templates and evaluation forms for the type of action under this topic:
IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):
Summary of the most relevant provisions for participating in IMI2 actions
Standard evaluation form
Proposal templates are available after entering the submission tool SOFIA.
IMI2 Model Grant Agreement
Template for Essential Clinical Trials Information
 
Please read carefully all provisions below before the preparation of your application !
You can access the description of the different topics in the IMI2 Call 9 topics text 
The budget breakdown for this Call is given at the end of the Call topics text, in the Call Conditions section (starting page 61), as well as the following information :
List of countries and applicable rules for funding
 
Eligibility and admissibility conditions
Evaluation criteria and procedure, scoring and threshold: described in the Manual for submission, evaluation and grant award      
 
Indicative timetable for evaluation and grant agreement
Provisions, proposal templates and evaluation forms for the type of action under this topic:
IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):
Summary of the most relevant provisions for participating in IMI2 actions
Standard evaluation form
Proposal templates are available after entering the submission tool SOFIA.
IMI2 Model Grant Agreement
Template for Essential Clinical Trials Information
 
Garantías:
No exige Garantías
No existen condiciones financieras para el beneficiario.

Información adicional de la convocatoria

Efecto incentivador: Esta ayuda tiene efecto incentivador, por lo que el proyecto no puede haberse iniciado antes de la presentación de la solicitud de ayuda. + info.
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Meses de respuesta:
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