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StemMemo

Financiado

What does your blood remember? The memory of hematopoietic stem cells.

Human organism produces over a million new blood cells each second. The hematopoietic system dynamically reacts to environmental stress and forms adaptive immunity to memorize and effectively fight the encounter pathogens. However... ver más

31/05/2027

UNIWERSYTET JAGIEL...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

UNIWERSYTET JAGIELLONSKI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-04-12

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIWERSYTET JAGIELLONSKI

2.50M€ | Lider

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Duración del proyecto: 61 meses Fecha Inicio: 2022-04-12
Fecha Fin: 2027-05-31

Líder del proyecto

UNIWERSYTET JAGIELLONSKI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto Human organism produces over a million new blood cells each second. The hematopoietic system dynamically reacts to environmental stress and forms adaptive immunity to memorize and effectively fight the encounter pathogens. However, based on our recent studies and preliminary results, we propose that the adaptive capabilities and memory of the hematopoietic system reach far beyond the classical adaptive antigen-specific immunity. We hypothesize that hematopoietic stress induces clonal expansion of lineage-biased hematopoietic stem cells (HSCs) with epigenetic memory that faster and more effectively respond to secondary stimulation with a given stress factor. We propose that lineage-biased HSCs accumulating during aging provide a broad adaptive memory of the hematopoietic system, that is not restricted to immune cells, but includes all blood cell lineages. The aim of our proposal is to understand how the HSC-stored memory is created, maintained and recalled, and to clarify the underlying mechanisms. First, we will selectively stimulate granulopoiesis, erythropoiesis and thrombopoiesis to define the specificity and physiological role of hematopoietic memory provided by HSCs, both in vitro and in vivo. Second, we will use single-cell level fate mapping and sequencing to investigate clonal and epigenetic mechanisms driving the HSCs-based memory in mice. Third, we will test if aging pool of human HSCs consists of lineage-biased HSCs that store memory of the previously encountered stimuli. The humanized mice models will determine the clonal expansion of human HSCs upon primary and secondary stimulation with stress factors. Altogether, the expected outcome of the project is to understand how and why hematopoietic system adjusts to the environmental challenges upon aging. The proposed novel concept of the hematopoietic system adaptivity may help to design strategies to train patients' hematopoiesis and improve the transplantations of HSCs.

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