Virtual Physiological and Computational Neuromuscular Models for the Predictive...
Virtual Physiological and Computational Neuromuscular Models for the Predictive Treatment of Parkinson s nDisease
NoTremor aims to provide patient specific computational models of the coupled brain and neuromuscular systems that will be subsequently used to improve the quality of analysis, correlation (of novel and established indicators) and...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
OpenMIND
Opto-Electronic Neural Connectoid Model Implemented for Neur...
3M€
Cerrado
RYC2020-029494-I
Humanized models to study neurodegeneration and Alzheimers d...
324K€
Cerrado
BES-2014-068173
REORGANIZACION DE LAS REDES CEREBRALES IMPLICADAS EN LA COGN...
88K€
Cerrado
C7
Cerebellar Cortical Control Cells Circuits Computation a...
4M€
Cerrado
Dynamic PET/MR
Dynamic PET MR New reconstruction methods for Parametric I...
162K€
Cerrado
RYC-2008-02190
The structural basis of cognitive impairment in Alzheimer's...
192K€
Cerrado
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
NoTremor aims to provide patient specific computational models of the coupled brain and neuromuscular systems that will be subsequently used to improve the quality of analysis, correlation (of novel and established indicators) and progression of Parkinson's disease. In particular, it aspires to establish the neglected link between brain modelling and neuromuscular systems that will result in a holistic representation of the physiology for PD patients. A significant breakthrough of NoTremor is that these models will not be used for abstract representation of the physiology or as a match between theory and clinical measurements. NoTremor will integrate computational models of the basal ganglia and brainstem into a unique multi-scale parametric computational model that can be subsequently simulated in the NoTremor simulation engine in a physics-based manner. NoTremor will revolutionize research in the pathophysiology of neurodegenerative movement disorders and provide a novel approach for their analysis founded on a solid computational modelling basis that links midbrain degenerations to motor behaviour. The computational models will be quantified and validated through test campaigns with a very large cohort of PD patients. The ultimate challenging use of the NoTremor virtual patient models will be from the one side clinical decision support and from the other side the investigation, virtual prototyping and modeling of the influence of dopamine levels testing of new drugs using virtual patient models.