Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

mRNA-DEG-RIBOSOME

Financiado

Cerrado

Understanding molecular principles of regulated mRNA degradation on translating...

Understanding molecular principles of regulated mRNA degradation on translating ribosomes Cell tightly regulate mRNA processing, localisation and stability to ensure accurate gene expression in diverse cellular states and conditions. Most of these mRNA regulation steps have traditionally been thought to primarily happe... ver más

30/09/2023

UKRI

213K€

Presupuesto del proyecto: 213K€

Líder del proyecto

UNITED KINGDOM RESEARCH AND INNOVATION No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-09-30

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UKRI

212.93K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2009-07510 REGULACION DE LA EXPRESION GENICA MEDIADA POR OPERONES POST-... 97K€ Cerrado

BFU2013-48643-C3-1-P REGULACION CRUZADA ENTRE LA TRANSCRIPCION Y LA ESTABILIDAD D... 278K€ Cerrado

DEAD2THEEND RNA poly A tail the beginning of the end 2M€ Cerrado

TERMINATOR Ribosomal frameshifts as a novel mechanism to control RNA tu... 192K€ Cerrado

mRNP-PackArt Nuclear mRNA Packaging and mRNP Architecture 2M€ Cerrado

BFU2011-30121 DESVELANDO LOS CIRCUITOS DE REGULACION GENICA DEFINIDOS POR... 581K€ Cerrado

Duración del proyecto: 30 meses Fecha Inicio: 2021-03-09
Fecha Fin: 2023-09-30

Líder del proyecto

UNITED KINGDOM RESEARCH AND INNOVATION No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 213K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cell tightly regulate mRNA processing, localisation and stability to ensure accurate gene expression in diverse cellular states and conditions. Most of these mRNA regulation steps have traditionally been thought to primarily happen before translation. However, recent discoveries highlight the role of nascent polypeptides on translating ribosomes in the active regulation of mRNAs. As the nascent protein emerges from the ribosome, it marks the identity of the encoding mRNA by its unique amino acid sequence. This allows cotranslational engagement by specific polypeptide recognition factors on the ribosome, providing them access to the associated mRNA. A striking example for such regulation is the negative feedback loop in the expression of tubulins known as tubulin autoregulation. In this case, tubulin mRNA is degraded cotranslationally when cells sense excess free tubulin, which is critical during mitosis to ensure faithful chromosome segregation. Recently, the first specific factor in this pathway has been identified: TTC5 recognises the N-terminus of nascent tubulin emerging from the translating ribosome and triggers degradation of the associated mRNA. However, the events leading to tubulin mRNA decay downstream of TTC5 remain elusive. In mRNA-DEG-RIBOSOME I will use tubulin autoregulation as a model system to study how the nascent chain on translating ribosomes directs mRNA degradation. Specifically, I aim to: (1) identify factors acting downstream of TTC5 required for tubulin mRNA degradation using cutting-edge mass spectrometry and genetic screening methods; (2) understand the mechanistic role of each factor in TTC5-directed mRNA degradation by using a powerful in vitro reconstitution approach; and (3) expand the understanding of nascent chain-dependent mRNA degradation by investigating related feedback systems. Thus, my work will to provide a conceptual framework for how cells have evolved to exploit nascent polypeptide recognition to direct mRNA fate.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores