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EpigeneticScars

Financiado

Understanding DSB repair from pathway choice to long term effects and their cons...

DNA safekeeping is one of the most important functions of the cell. Since DNA damage occurs in the context of chromatin, it affects both the DNA itself, but also the epigenetic landscape. While the repair mechanism of the DNA has... ver más

31/07/2025

BGU

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

BENGURION UNIVERSITY OF THE NEGEV No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-12-05

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

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2 Participantes

BGU

1.50M€ | Lider

BERNARDO ECENARRO

551.04K€ | Participante

Últimas noticias

27-11-2024: Videojuegos y creaci... Se abre la línea de ayuda pública: Ayudas para la promoción del sector del videojuego, del pódcast y otras formas de creación digital

27-11-2024: DGIPYME En las últimas 48 horas el Organismo DGIPYME ha otorgado 1 concesiones

27-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 2 concesiones

Duración del proyecto: 67 meses Fecha Inicio: 2019-12-05
Fecha Fin: 2025-07-31

Líder del proyecto

BENGURION UNIVERSITY OF THE NEGEV

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto DNA safekeeping is one of the most important functions of the cell. Since DNA damage occurs in the context of chromatin, it affects both the DNA itself, but also the epigenetic landscape. While the repair mechanism of the DNA has been extensively studied, questions abound regarding the restoration of the epigenetic landscape, and the long-term effects that damage leaves in the region. In this proposal I aim to address these questions using modified DSBs repair sensors from different pathways such as homologous recombination and non-homologous end joining to map the repair process. Our method will allow us to investigate the influence of the natural epigenetic landscape on pathway choice, the dynamic process of repair and the restoration of the region. Moreover, we will investigate whether certain repair processes leave long- lasting effects at the site of damage or even epigenetic scars. The advantage of our method is that it allows us to map each sensor repair time-line in an unbiased and high throughput manner over extended periods of time, even once the damage is already repaired. These questions are especially important for our understanding of ageing, and age-related diseases that are driven by DNA damage. Last, we will test the long-lasting effects of past damage in two different contexts: animal models of neurodegeneration, where DNA damage accumulates, and in the efficiency of reprograming to produce healthy induced pluripotent stem cells (IPCs).

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