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Malaria POC

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Cerrado

Ultrasensitive detection of transmissible malaria

Malaria affects millions around the globe. Affordable and accurate point-of-care diagnostic tests are needed for those in low- or middle-income countries as well as developed areas. Currently, only diagnostic tests for infection a... ver más

31/03/2021

IMPERIAL COLLEGE O...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-03-31

ERC-2019-POC: ERC Proof of Concept Grant

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Cerrada hace 6 años

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2 Participantes

IMPERIAL COLLEGE OF SCIENCE...

150.00K€ | Lider

HIBRAMER SA EN LIQUIDACION

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Duración del proyecto: 20 meses Fecha Inicio: 2019-07-30
Fecha Fin: 2021-03-31

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Malaria affects millions around the globe. Affordable and accurate point-of-care diagnostic tests are needed for those in low- or middle-income countries as well as developed areas. Currently, only diagnostic tests for infection are available and are most commonly designed to detect histidine-rich protein 2 (HRP2), though HRP2-negative parasites evolved and escape detection by these tests. In addition to detecting and curing infection, another important strategy against malaria is battling transmission by inhibiting gametocytes to carry the disease from humans back to mosquitoes. However, there are no available point-of-care diagnostic tests capable of testing for malaria transmission competency. Within Malaria POC we aim to design a lateral flow-based test capable of detecting antigens corresponding to transmission competency, for use at the point-of-care. Our programme has expertise in designing point-of-care tests by incorporating platinum core-shell nanoparticles (PtNCs) called nanozymes, which facilitate an amplification step of the signal in the presence of antigen. Within this POC grant we aim to incorporate catalytic nanozymes in a lateral-flow diagnostic test that detects activation of mature gametocytes. Prof Molly Stevens (www.stevensgroup.org) will exploit technologies developed in the ERC Consolidator grant NATURALE CG (616417) and will be supported through collaborations with Prof Jake Baum, Professor of Cell Biology and Infectious Diseases at Imperial College London, an expert in malaria parasites.

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