Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

Plakortide

Financiado

Cerrado

Towards an enantioselective synthesis of Plakortide P and its application to the...

Towards an enantioselective synthesis of Plakortide P and its application to the development of drugs for the treatment of Chagas disease African sleeping sickness, leishmaniasis and Chagas disease are all examples of orphan diseases, so named for the overall lack of attention given to them by major pharmaceutical companies. The infectious agent of the disease is Tr... ver más

04/09/2013

UCC

205K€

Presupuesto del proyecto: 205K€

Líder del proyecto

UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2013-09-04 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UCC

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

EUIN2017-88673 NUEVAS TERAPIAS BASADAS EN LA INHIBICION DE ENZIMAS ESPECIFI... 24K€ Cerrado

BES-2010-032058 AGENTES QUIMIOTERAPICOS FRENTE A PATOGENOS AMPLIAMENTE DISEM... 43K€ Cerrado

NovInDXS Development of novel inhibitors of the anti infective target... 171K€ Cerrado

PID2019-104070RB-C21 DISEÑO Y SINTESIS DE ENTIDADES QUIMICAS INNOVADORAS FRENTE A... 315K€ Cerrado

SAF2009-10399 DESARROLLO DE NUEVOS AGENTES QUIMIOTERAPICOS PARA ENFERMEDAD... 145K€ Cerrado

CTQ2013-48917-C3-1-P QUIMICA SUPRAMOLECULAR MEDICA. ACTIVIDAD ANTIPARASITARIA Y/O... 180K€ Cerrado

Líder del proyecto

UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 205K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto African sleeping sickness, leishmaniasis and Chagas disease are all examples of orphan diseases, so named for the overall lack of attention given to them by major pharmaceutical companies. The infectious agent of the disease is Trypanosoma cruzi. Between 8 to 11 million people in Mexico, Central America, and South America are estimated to have Chagas disease, most of whom do not know they are infected. If untreated, infection is lifelong and can be life threatening. Recently, the Plakortis species have proven to be a rich source of bioactive cycloperoxides - broadly classified as ‘Plakortides’ - which are reportedly highly selective against T. cruzi. This research proposal aims to answer the following questions: 1) Can the enantioselective peroxidation of unsaturated aldehydes be developed and applied to a synthesis of the Plakortides? 2) Can high potency analogues be synthesised through modification of the olefinic side chain? 3) Will stabilisation of radical metabolites lead to novel analogues with superior activity as potential therapies? In this project, the fellow will lead a ‘state of the art’, multidisciplinary research programme in a world class European research environment and host. The fellow will develop novel methods in organocatalysis for preparing chiral cycloperoxides, which will be applied to the complex natural products. In turn, this methodology will facilitate the production of aromatic analogues of Plakortide and potentially effective treatments for Chagas disease. Included in the fellowhip is an extensive training programme incorporating many career-enhancing modules and elements. A joint collaboration will run between Irish and UK universites with the fellow visiting both laboratories where he can broaden his skills from chemistry into biology and biochemistry. The project, therefore, represents an excellent opportunity for a talented fellow with ‘transfer of knowledge’ placed at its core.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores