Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

inhibitAUTO

Financiado

Cerrado

Towards a New Frontier in Autophagy Inhibition The Development of a Novel Class...

Towards a New Frontier in Autophagy Inhibition The Development of a Novel Class of Chemical Probes and Identification of Their Associated Biological Target This action aims to discover a novel class of autophagy inhibitors and newly develop chemical probes that can identify their protein targets and dissect their biological mode of action. Autophagy dysregulation is intrinsically lin... ver más

29/02/2020

MPG

171K€

Presupuesto del proyecto: 171K€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-02-29

MSCA-IF-2017: Individual Fellowships

I+D

Cerrada hace 7 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

MPG

171.46K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

Pyrroloindole Synthesis of molecular probes for cancer research based on p... 200K€ Cerrado

CTQ2008-02800 DISEÑO, SINTESIS Y EVALUACION BIOLOGICA COMO AGENTES ANTICAN... 202K€ Cerrado

RTI2018-094356-B-C21 BUSQUEDA E IDENTIFICACION DE NUEVAS MOLECULAS MODULADORAS DE... 182K€ Cerrado

LIPOPROT New chemical tools for profiling protein lipidation in cance... 209K€ Cerrado

NPL Synthesis of Natural Product Like Compounds for Drug Discove... 176K€ Cerrado

SAF2009-11955 DISEÑO Y SINTESIS DE NUEVOS INHIBIDORES MEJORADOS DE COLINA... 145K€ Cerrado

Duración del proyecto: 24 meses Fecha Inicio: 2018-02-19
Fecha Fin: 2020-02-29

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 171K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto This action aims to discover a novel class of autophagy inhibitors and newly develop chemical probes that can identify their protein targets and dissect their biological mode of action. Autophagy dysregulation is intrinsically linked with major European healthcare challenges, including cancer. The identification of new classes of druggable autophagic proteins will have broad implications for the development of novel and more effective cancer therapeutics. To address the aims of this action, this proposal seeks support to initiate a pioneering and holistic chemical biology programme, which combines the newest technologies in synthetic chemistry and cell biology. Phenotypic investigations in the host lab recently identified new inhibitors of autophagy based on a novel scaffold, which modulates autophagy through an exciting but unknown pathway. In this action the use of a newly introduced sp2-sp3 cross-coupling reaction will allow systematic variation of the scaffold, exploration of its structure-activity relationship, and improvement of the potency of these inhibitors to facilitate the preparation of high-quality chemical probes. A focused compound collection (>100 compounds) will be prepared and investigated in cell-based assays, with the aim of establishing a broad, potent and selective class of inhibitors. The inhibitory mode of action will then be rationalised through identification, validation and engagement of the associated biological targets using further cell-based investigations and biophysical assays. Chemical probes will be generated from the most active inhibitors and used to identify and interrogate the druggability of a novel protein target with potentially huge significance for biomedical science. My ambition is to become an independent academic researcher in chemical biology at a leading European institution, and this Fellowship provides a vital opportunity for me to advance my scientific and career potential.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores