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ChroMOS

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Toward monolithic CMOS based neural probes for stable chronic recording and brai...

Toward monolithic CMOS based neural probes for stable chronic recording and brain machine interfaces The recent advent of active high-density implantable neural probes based on CMOS technology is a big leap forward in neuroscience. Unprecedentedly, these new probes provide simultaneous access to several thousands of single-neuron... ver más

31/10/2022

IIT

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-10-31

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IIT

183.47K€ | Lider

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Duración del proyecto: 30 meses Fecha Inicio: 2020-04-14
Fecha Fin: 2022-10-31

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The recent advent of active high-density implantable neural probes based on CMOS technology is a big leap forward in neuroscience. Unprecedentedly, these new probes provide simultaneous access to several thousands of single-neurons in different brain circuits. Although realized with different circuit’s architectures, such devices combine the use of standard CMOS and MEMS technologies to realize monolithic active dense probes that integrate into the same substrate hundreds of closely spaced microelectrodes together with electronic circuits for recording extracellular bioelectrical signals. However, despite their unique value, current CMOS-probes are not yet adapted for chronically stable implants and this is a major drawback both for neuroscience research as well as for growing potential clinical applications in fields such as brain-machine-interfaces or neuroprosthetics. An emerging hypothesis to minimize tissue-reactions and improve chronic stability of implantable probes consists in downscaling the cross-sectional sizes of their shafts as well as the overall system size. This fellowship proposes a deep study of this hypothesis by exploiting key advantages of monolithic CMOS based neural probes together with the optimization of circuits, materials and microfabrication processes. I will exploit my background in MEMs technologies and acquire new expertise in neuroscience to evaluate solutions for reducing CMOS shanks dimensions (20-80 µm width, 15-30 µm thick), strategies to improve tissue-materials interfaces, and to assess the effects of these features on brain tissue responses and recording performances. This will lead to ChroMOS probes with a very thin and uniform width (tens of microns) through all the shaft, and with electrode densities up to 1000 sites/mm2. This can lead to remarkably stable probe’s implants with large-scale single-neuron recording capabilities, far behind current technologies.

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