Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

DevCycle

Financiado

Timing cell cycles in multicellular development

Animal development depends on precisely timed cell divisions, which ensure the formation of tissues and organs with specific architectures and functions. As cells differentiate and mature, they need to modify the expression of cel... ver más

31/05/2027

KNAW

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCH... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-05-06

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

KNAW

1.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2008-00365 DEFINIENDO UNA RED REGULATORIA TRANSCRIPCIONAL QUE CONTROLA... 230K€ Cerrado

DynaTrans Transcription in 4D: the dynamic interplay between chromatin... 10M€ Cerrado

BFU2015-65728-P ESPECIFICACION TERRITORIAL Y CONTROL DE LA PROLIFERACION DUR... Cerrado

EmbryoCellEnsemble How do cells form an embryo: Intracellular, temporal, and ph... 2M€ Cerrado

BFU2013-41322-P DINAMICA DEL EPIGENOMA Y DE LOS PAISAJES REGULADORES DURANTE... 508K€ Cerrado

MorphoNotch Multi scale analysis of the interplay between cell morpholog... 2M€ Cerrado

Duración del proyecto: 60 meses Fecha Inicio: 2022-05-06
Fecha Fin: 2027-05-31

Líder del proyecto

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCH... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Animal development depends on precisely timed cell divisions, which ensure the formation of tissues and organs with specific architectures and functions. As cells differentiate and mature, they need to modify the expression of cell-cycle regulators in order to achieve tissue-specific division patterns. It is largely unknown how cells coordinate cell-cycle gene expression changes with developmental timing and how cell cycles can be altered to give rise to different tissue architectures and organ sizes. DevCycle will address these questions by studying intestinal cell cycles in nematodes. I have recently pioneered tools to measure mRNA expression changes and chromatin modifications in purified intestinal cells from C. elegans, which we will use to uncover how the expression of cell-cycle genes is changing during development and to identify novel regulators that control stage-specific gene expression. Moreover, I will implement a novel microfluidics platform for long-term imaging of larval development to identify the mechanisms that allow temporal coupling of cell cycle and development. This system will allow us to visualize and manipulate transcription factor gradients that direct intestinal cell cycles, providing unprecedented insights into how cell cycles are timed. Finally, I will analyse the mechanisms that control cell-cycle behaviour in P. redivivus, a related nematode in which intestinal cells undergo a slightly different cell-cycle pattern. Expanding our analyses to this species will empower us to investigate how cell-cycle patterns can diversify to generate phenotypic variability. Together, this research program will develop a mechanistic understanding of the temporal control of cell cycles in development, revealing new paradigms on how tissue-specific division patterns arise. This knowledge will open up future avenues to modulate cell cycles for tissue engineering purposes, as well as to control cell divisions in disease.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores