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SymFlux

Financiado

The role of symbiont diversity in resilience to temperature fluctuations.

Beneficial microbes are essential for many animals and mutualistic interactions must be able to withstand environmental changes such as temperature fluctuations. However, with changing ocean temperatures induced by climate change,... ver más

31/08/2026

SORBONNE UNIVERSIT...

212K€

Presupuesto del proyecto: 212K€

Líder del proyecto

SORBONNE UNIVERSITE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-17

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

SORBONNE UNIVERSITE

211.75K€ | Lider

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Duración del proyecto: 28 meses Fecha Inicio: 2024-04-17
Fecha Fin: 2026-08-31

Líder del proyecto

SORBONNE UNIVERSITE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 212K€

Descripción del proyecto Beneficial microbes are essential for many animals and mutualistic interactions must be able to withstand environmental changes such as temperature fluctuations. However, with changing ocean temperatures induced by climate change, it is unclear whether symbioses will be able to adapt, leaving marine organisms at risk. Therefore, this proposal will characterize how bacterial symbionts respond to changing temperatures and identify whether microbes can increase symbiotic resiliency to temperature stress. To pursue this topic, the symbiosis between the squid Sepiola affinis and its symbionts (V. fischeri and V. logei) will be used. The project uses a unique squid husbandry facility to pursue three main objectives. The first objective will characterize initial and persistent colonization in the S. affinis light organ. Using confocal microscopy and genetic labelling, strain behaviors during colonization will be described. The second objective will examine how temperature affects colonization. The third objective will screen Vibrio spp. for growth under temperature fluctuations. RNA sequencing and metabolomics will be used to identify molecular mechanisms underlying resilience to temperature fluctuations. Finally, genetic modification and both in-vitro and in-vivo growth assays will test whether molecular candidates promote temperature resilience. The project will have a two-way transfer of knowledge, with the researcher providing knowledge of Vibrio spp. and bacterial genetics with the host institution providing bioinformatics and small molecule analysis. The SymFlux project will position S. affinis as a model for symbiosis research in Europe as well as contribute knowledge of how symbioses can adapt to climate change.

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