Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CLLRISK

Financiado

Cerrado

The germline mutational landscape of chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a cancer of B-lymphocytes, which expands in the bone marrow, lymph nodes, spleen and blood. While many genes have been implicated in CLL development through sequencing the genome of tumor cell... ver más

20/06/2016

FUNDACIO PRIVADA C...

230K€

Presupuesto del proyecto: 230K€

Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-06-20 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FUNDACIO PRIVADA CENTRE DE R...

0.00€ | Lider

Proyectos interesantes

SAF2012-38432

Medical Technol...

Data Science

328K€ Cerrado

BES-2013-062645

Medical Technol...

Data Science

84K€ Cerrado

PID2021-123165OB-I00

Medical Technol...

Data Science

266K€ Cerrado

BASIS

Medical Technol...

Data Science

14M€ Cerrado

CLL_INCLONEL

Medical Technol...

Data Science

261K€ Cerrado

BCLLatlas

Medical Technol...

Data Science

8M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 230K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Chronic lymphocytic leukemia (CLL) is a cancer of B-lymphocytes, which expands in the bone marrow, lymph nodes, spleen and blood. While many genes have been implicated in CLL development through sequencing the genome of tumor cells, they do not completely explain the pathogenesis of the disease, nor define the early events that lead the B-cells to proliferate and become cancerous, accumulating the different types of somatic mutations of CLL. Most sequencing studies have focused only on discovery of somatic mutations without investigating germline risk variants. The aim of this project is to identify the landscape of germline risk factors that can predispose an individual to CLL. We will utilize whole-genome and exome-sequencing data on 100 and 500 CLL cases (normal and tumor samples) respectively, from the Spanish CLL consortium (International Cancer Genome Consortium). We will identify recurrent predicted damaging germline mutations. The results from relevant genes will be replicated in a larger cohort of cases and controls. The 20 most important genes accumulating damaging germline mutations in CLL patients (preliminary results involve cell-cycle, DNA damage checkpoint, double-strand break repair genes) will be tested at the functional level to evaluate the nature of the biological processes that are enriched in CLL. We will either use Saccharomyces cerevisiae or cell lines as model systems for functional analyses of the selected genes. We will also then implement other systems, such as Caenorhabditis elegans or Danio rerio models, for which convergent data on mutations in the altered pathways have been obtained. We expect to identify the complete spectrum of susceptibility genes involved in the early stage of development of this type of leukemia and advance the understanding of its pathogenesis.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores