Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

GUT GENE REGULATION

Financiado

Cerrado

TCF4 transcriptional program in crypt stem cells and resulting differentiated ce...

TCF4 transcriptional program in crypt stem cells and resulting differentiated cells The Wnt pathway is a key regulatory pathway in development and carcinogenesis. Many of the components of the pathway connecting Wnt to the transcription factor TCF4 have been identified. However, our knowledge of the regulation of... ver más

28/02/2010

ERASMUS MC

227K€

Presupuesto del proyecto: 227K€

Líder del proyecto

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2010-02-28 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

ERASMUS MC

0.00€ | Lider

KNAW

N.D. | Participante

Proyectos interesantes

WNTLINCS

Medical Technol...

Data Science

100K€ Cerrado

BFU2017-88265-P

Medical Technol...

Data Science

293K€ Cerrado

CRC PROGRAMME

Medical Technol...

Data Science

2M€ Cerrado

BFU2013-42709-P

Medical Technol...

Data Science

254K€ Cerrado

BFU2010-21794

Medical Technol...

Data Science

109K€ Cerrado

BFU2014-57216-P

Medical Technol...

Data Science

278K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 227K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The Wnt pathway is a key regulatory pathway in development and carcinogenesis. Many of the components of the pathway connecting Wnt to the transcription factor TCF4 have been identified. However, our knowledge of the regulation of TCF4 promoter and enhancer elements in response to the Wnt signal, resulting in development from a stem cell to a differentiated cell, is limited. Largely due to technical constrains it has not been possible to identify TCF4 bound DNA enhancer elements or protein complexes associated with them which dictate specificity of the Wnt signal in the developing tissue. The mouse intestinal epithelium is a rapidly renewing tissue under the control of the canonical Wnt pathway, and therefore ideal to study the above mentioned questions. The proposed project combines state of the art ChIP on chip Genome wide Agilent DNA arrays, Mass Spectrometry, Flow Cytometry, as well as conventional Biochemistry and Molecular Biology to examine Wnt/TCF4 controlled intestinal development in mice. Using these techniques I will identify distal TCF4 regulatory elements, the associated promoters and the protein complexes responsible. Study of the associated complexes and epigenetic marks will help to identify mechanism of activation and repression of the Wnt pathway resulting in the differentiation from a stem cell to a differentiated cell. Stem cells and their development or the misregulation resulting in tumor growth are of major interest to the academic as well pharmaceutical world for their potential use in treatment (stem cells) or the need for a cure (cancer). Therefore it is important to understand how these processes are regulated in vivo. Research in this ever expanding field is very important to maintain Europe’s scientific excellence in the future.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores