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CARBAZYMES

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Sustainable industrial processes based on a C C bond forming enzyme platform

C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challen... see more

31/03/2019

TECHNISCHE UNIVERS...

9M€

Project Budget: 9M€

Project leader

TECHNISCHE UNIVERSITAT DARMSTADT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 15 Participantes

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2019-03-31

BIOTEC-3-2014: Widening industrial application of... Scope:Specific challenge: Biocatalysis is increasingly used in synthetic routes to complex molecules...

I+D

Cerrada does 11 years

0% 89% 100%

characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

15 Participantes

TECHNISCHE UNIVERSITAT DARMS...

1.47M€ | Leader

UAM

786.38K€ | participant

EVO

478.63K€ | participant

SUSTAINABLE MOMENTUM

109.20K€ | participant

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Project duration: 48 months Date Start: 2015-03-13
End date: 2019-03-31

Project leader

TECHNISCHE UNIVERSITAT DARMSTADT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 9M€

participation deadline Sin fecha límite de participación.

Project description C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project. Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners. CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.

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