Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PROPROTEINREGULATION

Financiado

Cerrado

Study of cis trans proline isomerization as a novel regulatory mechanism of prot...

Study of cis trans proline isomerization as a novel regulatory mechanism of protein function Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl ci... ver más

31/08/2016

FUNDACIO INSTITUT...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

FUNDACIO INSTITUT DE RECERCA BIOMEDICA IRB BA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 23M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-08-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FUNDACIO INSTITUT DE RECERCA...

0.00€ | Lider

Proyectos interesantes

Iso-Proline CTD

Medical Technol...

Applied Physics

219K€ Cerrado

STARIDP

Medical Technol...

Applied Physics

177K€ Cerrado

PROTEASE SIGNALING

Medical Technol...

Applied Physics

100K€ Cerrado

IDCHAPERONES

Medical Technol...

Applied Physics

100K€ Cerrado

BIO2012-39922-C02-02

Medical Technol...

Biotechnology

105K€ Cerrado

PyroPhosphoProtein

Medical Technol...

Biotechnology

183K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

FUNDACIO INSTITUT DE RECERCA BIOMEDICA IRB BA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 23M€

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function. Proline is the only amino acid in proteins that depending on the value of the ω angle of the peptidic bond can adopt two completely different conformations (cis or trans), which can have important consequences for protein structure. Furthermore, the slow inter-conversion between these two conformations provides a regulatory mechanism of protein structure and enzymes (named peptidyl prolyl isomerases, PPIases) able to catalyze the isomerization exist. The recent discovery of the phospho-specific PPIase Pin1 implied a new regulatory role for this family of enzymes. Pin1 has been shown to be involved in the control of cell-cycle, growth factors and apoptosis and its deregulation to be implicated in cancer, asthma and neurodegenerative diseases. However, the study of the exact effect of cis/trans proline isomerization in protein function and the role of PPIases (specifically Pin1) in biological networks has been deeply hampered by the intrinsic nature of this non-covalent modification which can be safely defined as the most subtle of the ones currently known. Here we propose to adopt a Chemical Biology approach in order to study some of the unanswered questions about Pin1 difficult to address through more traditional methods. We will try to elucidate Pin1’s mechanism of action, the different biological function between cis and trans conformations of its substrates and develop a new method to monitor its activity. We expect this project will make an important contribution towards the understanding of Pin1 in protein function regulation and the validation of its potential as a new therapeutic and diagnosis target for cancer.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores