Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SABDII

Financiado

Cerrado

Staphylococcus aureus biofilm dynamics and innate immunity

During my postdoc at a marine biotechnology lab in Newcastle I experienced that bacteria growing in shakeflasks in the lab and bacteria in natural biofilms behave very differently. For instance, the global gene expression and prod... ver más

31/08/2013

UMC UTRECHT

45K€

Presupuesto del proyecto: 45K€

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2013-08-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UMC UTRECHT

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PCIN-2015-151 STAPHYLOCOCCUS AUREUS INTRACELULAR: DESCIFRANDO LOS FACTORES... 142K€ Cerrado

S. AUREUS CLS Staphylococcus aureus cardiolipin production and role in hos... 100K€ Cerrado

COMPSTAPH Exploiting innate immune evasion strategies of Staphylococcu... 100K€ Cerrado

PROTEIN-BIOFILM Characterization of protein dependent biofilms by Staphyloco... 45K€ Cerrado

SAF2014-56986-R TRANSFERENCIA HORIZONTAL DE FACTORES DE VIRULENCIA CONTENIDO... 145K€ Cerrado

Septal_PG_Hydrolases Unravelling the mechanisms for recruitment and activation of... Cerrado

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 45K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto During my postdoc at a marine biotechnology lab in Newcastle I experienced that bacteria growing in shakeflasks in the lab and bacteria in natural biofilms behave very differently. For instance, the global gene expression and production of secreted proteins is very different between these modes of growth. I would like to bring the knowledge and skills acquired there to a higher level by studying the interaction between a clinically relevant biofilm and host organism. To achieve this, I will study the dynamics of Staphylococcus aureus biofilms in interaction with the human innate immune system in the laboratory of Prof. van Strijp in Utrecht. S. aureus is a Gram-positive coccus that causes life threatening diseases and has become resistant against most antibiotics (MRSA). Our innate immune system is crucial in fighting S. aureus infections. Strikingly, S. aureus evades this defence line by production of small secreted proteins that repress this immune system. In many infections, S. aureus’ growth mode is generally considered to be biofilm-like. Using a novel, biofilm centred approach I will study the interaction between the innate immune system and S. aureus. By comparing planktonic growth with several biofilm stages using proteomic analysis, I will screen for novel immune evasion molecules that are expressed specifically during the biofilm mode of growth of S. aureus. The identified proteins will be studied further using deletion mutants in S. aureus and the proteins will be overexpressed in heterologous hosts, such as E. coli or B. subtilis. Using the mutant strains and the overproduced proteins, the specific interactions of these novel proteins with the innate immune system will be examined, both in vitro and in vivo. The identified molecules will be highly interesting drug targets against a problematic microbial pathogen

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores