Innovating Works

SmartNanoTox

Financiado
Smart Tools for Gauging Nano Hazards
A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent carefu... A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future. ver más
30/09/2020
NUID UCD
8M€
Duración del proyecto: 55 meses Fecha Inicio: 2016-02-26
Fecha Fin: 2020-09-30

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2020-09-30
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
NMP-29-2015: Increasing the capacity to perform nano-safety assessment
Cerrada hace 9 años
Presupuesto El presupuesto total del proyecto asciende a 8M€
Líder del proyecto
UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5