HORIZON EUROPE
Europeo
Scope:Specific challenge: Systems biology, high throughput screening and toxicogenomics approaches have the potential to revolutionise how chemical substances, including nanomaterials, are assessed for regulatory and risk management purposes. A paradigm shift in toxicology using innovative techniques such as High Thoughput Screening (HTS) approaches, Toxicogenomics and High Content Analysis (HCA) is being established. With such approaches it is possible to identify underlying affected pathways (so called ‘toxicity pathways’). The challenge is to develop and demonstrate a mechanism-based understanding of toxicity, which will enable improved toxicity testing by identifying novel endpoints essential to tailor-made first tier hazard and risk assessment of novel and emerging materials.
Scope: Projects should enhance the understanding of the mechanisms underlying any observed adverse effects from engineered nanomaterials, and ultimately link the potential for such adverse effects to specific physical or chemical nano scale properties.
They should establish and demonstrate the basis for the development of appropriate tools to maximise read across (taxa and nano...
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Scope:Specific challenge: Systems biology, high throughput screening and toxicogenomics approaches have the potential to revolutionise how chemical substances, including nanomaterials, are assessed for regulatory and risk management purposes. A paradigm shift in toxicology using innovative techniques such as High Thoughput Screening (HTS) approaches, Toxicogenomics and High Content Analysis (HCA) is being established. With such approaches it is possible to identify underlying affected pathways (so called ‘toxicity pathways’). The challenge is to develop and demonstrate a mechanism-based understanding of toxicity, which will enable improved toxicity testing by identifying novel endpoints essential to tailor-made first tier hazard and risk assessment of novel and emerging materials.
Scope: Projects should enhance the understanding of the mechanisms underlying any observed adverse effects from engineered nanomaterials, and ultimately link the potential for such adverse effects to specific physical or chemical nano scale properties.
They should establish and demonstrate the basis for the development of appropriate tools to maximise read across (taxa and nano properties) and assess which tools or endpoints may not necessarily be applicable across the board. These approaches should aim to support the grouping of nanomaterials, to help in developing intelligent testing strategies and identifying "nanomaterials or properties of concern" that need to be tested more thoroughly.
Activities expected to focus on Technology Readiness Level 4.
The Commission considers that proposals requesting a contribution from the EU between EUR 4 and 8 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.
Expected impact:
• New screening tools to enhance the efficiency of end-rate at which nanomaterial hazard profiling can be performed
• Facilitate faster definition of nanomaterials toxicity mechanisms
• Enable “safer by design” approaches, tailored to stakeholders’ needs (modellers, industry and regulators)
• Data in a recognised and accessible database for use beyond the lifetime of the project
• Provision of solutions to the long-term challenges of nanosafety and nanoregulation
Type of action: Research and Innovation Actions
Cross-cutting Priorities:International cooperation
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Características del consorcio
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La ayuda es de ámbito europeo, puede aplicar a esta linea cualquier empresa que forme parte de la Comunidad Europea.
Características del Proyecto
Los costes de personal subvencionables cubren las horas de trabajo efectivo de las personas directamente dedicadas a la ejecución de la acción. Los propietarios de pequeñas y medianas empresas que no perciban salario y otras personas físicas que no perciban salario podrán imputar los costes de personal sobre la base de una escala de costes unitarios
Los otros costes directos se dividen en los siguientes apartados: Viajes, amortizaciones, equipamiento y otros bienes y servicios. Se financia la amortización de equipos, permitiendo incluir la amortización de equipos adquiridos antes del proyecto si se registra durante su ejecución. En el apartado de otros bienes y servicios se incluyen los diferentes bienes y servicios comprados por los beneficiarios a proveedores externos para poder llevar a cabo sus tareas
La subcontratación en ayudas europeas no debe tratarse del core de actividades de I+D del proyecto. El contratista debe ser seleccionado por el beneficiario de acuerdo con el principio de mejor relación calidad-precio bajo las condiciones de transparencia e igualdad (en ningún caso consistirá en solicitar menos de 3 ofertas). En el caso de entidades públicas, para la subcontratación se deberán de seguir las leyes que rijan en el país al que pertenezca el contratante
Características de la financiación
List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
Eligibility and admissibility conditions: described in part B and C of the General Annexes of the General Work Programme.
Evaluation
3.1 Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme, with the following exceptions:
For single-stage and second-stage evaluations, the threshold for the criteria Excellence and Impact will be 4. The overall threshold, applying to the sum of the three individual scores, will be 12.
In case of equal overall scores in the ranked list, the priority order of proposals will be established in accordance with part H of the General Annexes, except that proposals will be ranked on the basis of individual scores for the Impact criterion before the Excellence criterion.
3.2 Guide to the submission and evaluation process
Proposal page limits and layout: Please refer to Part B of the standard proposal template.
Indicative timetable for evaluation and grant agreement:
Information on the outcome of two-stage evaluation: maximum 5 months from the final date for submission.
Signature of grant agreements: maximum 3 months from the date of inform... Please read carefully all provisions below before the preparation of your application.
List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
Eligibility and admissibility conditions: described in part B and C of the General Annexes of the General Work Programme.
Evaluation
3.1 Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme, with the following exceptions:
For single-stage and second-stage evaluations, the threshold for the criteria Excellence and Impact will be 4. The overall threshold, applying to the sum of the three individual scores, will be 12.
In case of equal overall scores in the ranked list, the priority order of proposals will be established in accordance with part H of the General Annexes, except that proposals will be ranked on the basis of individual scores for the Impact criterion before the Excellence criterion.
3.2 Guide to the submission and evaluation process
Proposal page limits and layout: Please refer to Part B of the standard proposal template.
Indicative timetable for evaluation and grant agreement:
Information on the outcome of two-stage evaluation: maximum 5 months from the final date for submission.
Signature of grant agreements: maximum 3 months from the date of informing successful applicants.
Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:
Research and Innovation Action:
Specific provisions and funding rates
Standard proposal template
Standard evaluation form
Annotated Model Grant Agreement
Additional provisions:
Horizon 2020 budget flexibility
Classified information
Technology readiness levels (TRL) – where a topic description refers to TRL, these definitions apply.
Financial support to Third Parties – where a topic description foresees financial support to Third Parties, these provisions apply.
Open access must be granted to all scientific publications resulting from Horizon 2020 actions, and proposals must refer to measures envisaged. Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.
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