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PID2020-117610RB-I00

Financiado

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SMALL MOLECULE TRANSMEMBRANE ANION CARRIERS FOR BIOLOGICAL APPLICATIONS

LIFE IS COMPARTMENTALISED BY MEMBRANES, WHICH SEPARATE THE INTERIOR OF THE CELLS FROM THE OUTSIDE ENVIRONMENT, A CHARACTERISTIC FEATURE OF THESE MEMBRANES IS THAT THEY ARE IMPERMEABLE TO SMALL IONS AND MACROMOLECULES, TRAFFICKING... ver más

01/01/2020

UBU

133K€

Presupuesto del proyecto: 133K€

Líder del proyecto

UNIVERSIDAD DE BURGOS No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 370

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2020-01-01 No tenemos la información de la convocatoria

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UBU

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Líder del proyecto

UNIVERSIDAD DE BURGOS No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 370

Presupuesto del proyecto 133K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto LIFE IS COMPARTMENTALISED BY MEMBRANES, WHICH SEPARATE THE INTERIOR OF THE CELLS FROM THE OUTSIDE ENVIRONMENT, A CHARACTERISTIC FEATURE OF THESE MEMBRANES IS THAT THEY ARE IMPERMEABLE TO SMALL IONS AND MACROMOLECULES, TRAFFICKING OF IONS IS TIGHTLY REGULATED THROUGH TRANSMEMBRANE PROTEINS, ALLOWING A PRECISE CONTROL OF ION CONCENTRATIONS AND PH, AND CREATING ELECTROCHEMICAL GRADIENTS VITAL TO CELL FUNCTION, DESIGNING, PREPARING AND STUDYING SYNTHETIC SYSTEMS CAPABLE OF MIMICKING THE FUNCTION OF TRANSMEMBRANE CHANNEL PROTEINS HAVE BEEN THE FOCUS OF NUMEROUS RESEARCH GROUPS, AND REPRESENTS ONE OF THE EARLY GOALS OF SUPRAMOLECULAR CHEMISTRY, ALTHOUGH SYNTHETIC IONOPHORES CAPABLE OF SELECTIVELY COORDINATING CATIONS SUCH AS CYCLIC POLYETHERS WERE EARLY DEVELOPED, ANIONOPHORES, IONOPHORES SELECTIVELY TRANSPORTING ANIONS, HAVE BEEN MAINLY STUDIED IN THE LAST TEN YEARS, THUS, THE DEVELOPMENT OF ANIONOPHORES IS NOT YET MATURE AND THE STUDY OF THE BIOLOGICAL APPLICATIONS OF THESE COMPOUNDS IS STILL IN ITS INFANCY, UPSETTING CELLULAR HOMEOSTASIS TO THE POINT OF INDUCING CYTOTOXICITY THAT CAN BE USEFUL FOR THE DEVELOPMENT OF ANTICANCER AGENTS OR ANTIMICROBIAL AGENTS, AND REPLACING THE MISSING OR FAULTY TRANSPORT ACTIVITY OF NATURAL TRANSPORT MECHANISMS IN THE CASE OF CHANNELOPATHIES (CONDITIONS DERIVED FROM THE MALFUNCTION OF NATURAL TRANSPORT MECHANISMS, CYSTIC FIBROSIS FOR INSTANCE),WITH OUR BACKGROUND AND EXPERIENCE IN THE SYNTHESIS OF STRUCTURALLY DIVERSE ANIONOPHORES AND THE STUDY OF THEIR BIOLOGICAL APPLICATIONS, IN THIS PROJECT PROPOSAL WE AIM AT PRODUCING AND STUDYING SMALL-MOLECULE ANION CARRIERS TARGETING SHORTCOMINGS IDENTIFIED IN THE FIELD TO ADVANCE THE POTENTIAL OF THESE COMPOUNDS AS FUTURE DRUGS, WE PROPOSE A VERSATILE DESIGN RECENTLY REPORTED BY OUR GROUP (CLICK-TAMBJAMINES) AS STARTING POINT FOR THE SYNTHESIS AND CHARACTERISATION OF SERIES OF ANIONOPHORES INCLUDING ANIONOPHORES TARGETING CELLULAR ORGANELLES, LIGHT-ACTIVATABLE PROANIONOPHORES AND STRUCTURALLY DIVERSE ANIONOPHORES BEARING PSEUDOPEPTIDIC MOIETIES, SECONDLY, WE WILL INVESTIGATE THE TRANSMEMBRANE ANION TRANSPORT ACTIVITY OF THE SYNTHESISED ANIONOPHORES IN MODEL LIPOSOMES, SPECIALLY THEIR ABILITY TO TRANSPORT ANIONS OF BIOLOGICAL INTEREST, SUCH AS BICARBONATE, CARBOXYLATES, SULFATES OR PHOSPHATES CURRENTLY UNDERSTUDIED, BY THE SAME TOKEN, WE WILL DEVELOP ANION TRANSPORT EXPERIMENTS AT ACIDIC PH, TO TRY TO REPRODUCE THE BIORELEVANT CONDITIONS, THE MOST PROMISING CANDIDATES WILL BE FORMULATED EMPLOYING NANOSTRUCTURED LIPID CARRIERS (NLCS), AND THEIR ANION TRANSPORT ACTIVITY WILL ALSO BE INVESTIGATED AND COMPARED WITH THAT OF THE FREE COMPOUNDS, ANTIMICROBIAL AND ANTIVIRAL ACTIVITY IN MULTI-DRUG RESISTANT BACTERIA AS WELL AS SARS-COV-2 AND OTHER VIRAL STRAINS, RESPECTIVELY, WILL BE STUDIED FOR THE FORMULATED AND NON-FORMULATED HIT COMPOUNDS, IONOFOROS\ENLACE DE HIDROGENO\LIPOSOMAS\SISTEMAS DE ADMINISTRACION DE FARMACOS

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