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Serial-X

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SERIAL CRYSTALLOGRAPHY SOLUTIONS FOR SYNCHROTRON RADIATION FACILITIES

Serial-X aims to expand of the use of serial crystallography across the academic and industrial life-science community by introducing low cost, flexible and easy to use solutions to the most common problems that occur in serial cr... ver más

30/04/2022

UGOT - GOETEBORGS...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

GOETEBORGS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-04-30

ERC-2020-POC: Call for proposals for ERC Proof of...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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2 Participantes

UGOT - GOETEBORGS UNIVERSITE...

150.00K€ | Lider

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Duración del proyecto: 19 meses Fecha Inicio: 2020-09-15
Fecha Fin: 2022-04-30

Líder del proyecto

GOETEBORGS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Serial-X aims to expand of the use of serial crystallography across the academic and industrial life-science community by introducing low cost, flexible and easy to use solutions to the most common problems that occur in serial crystallography experiments today. Serial crystallography is a developing method of macromolecular X-ray crystallography that allows diffraction data to be collected at room temperature from a continuous stream of microcrystals. ProtonPump, the ERC Advanced Grant awarded to Richard Neutze, applies time-resolved serial crystallography to observe structural changes that occur during the reduction of molecular oxygen to water by cytochrome c oxidase. This PoC builds directly from technical solutions developed to achieve the scientific goals of ProtonPump. Serial crystallography was first developed at an X-ray free electron laser but is increasingly being used at synchrotron radiation facilities. Synchrotrons can potentially support up to two orders of magnitude more serial crystallography users than X-ray free electron lasers. Synchrotron based serial crystallography experiments may also become a mainstream method in structure-based-drug-design. But these possibilities will not be realized if the current lack of standardization in sample delivery continues, which is currently prohibitively expensive and requires a high level of technical support to operate. Serial-X will solve this problem by developing and bringing to market standardized, low-cost, flexible and easy-to-use solutions for sample delivery in serial crystallography studies at synchrotron radiation sources. Serial-X will thereby remove the greatest obstacle currently preventing scientists from using serial crystallography for their own research or for structure based drug-design within a pharmaceutical drug discovery context. A spin off company will be formed to manufacture and distribute the technologies developed within this Proof of Concept Grant.

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