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Sensorimotor Integration, Motor Planning and Learning In FLY
We are constantly learning new motor skills throughout our life. Whether riding a bicycle or playing an instrument, motor learning relies on a calibration between sensory signals and internal motor information. Saccadic adaptation... We are constantly learning new motor skills throughout our life. Whether riding a bicycle or playing an instrument, motor learning relies on a calibration between sensory signals and internal motor information. Saccadic adaptation, the recalibration of fast eye rotations induced by visual error signals, has helped develop key insights into the identity of circuits, and the theoretical models underlying motor learning. However, how visual signals interact with internal movement representations during motor learning remains at present underdetermined. Taking advantage of the compact brain of the fly with well characterized visual pathways, and a plethora of anatomical, physiological, and genetic tools, here we propose to study motor learning in the context of goal-directed body saccades in D. melanogaster. We will monitor changes in body saccades consistent with repetitive visual perturbations by quantitative analysis of head-fixed flight behavior in an adapted version of the classical eye saccadic adaptation paradigm. In simultaneous, we will first record and then manipulate the activity of population of neurons known to contribute to body saccades, including visual descending neurons (VDNs) and their upstream synaptic partners, which as a network integrate visual signals and self-motion information with motor commands. Together, these experiments will establish unprecedented causal relationships among neural activity, learning, and the formation of a flexible internal representation for locomotor control. The functional principles identified in this project will establish a framework that can be tested in other species and behavioral contexts, and ultimately improve our understanding of motor learning with important implications both in health and disease. ver más
31/08/2025
FUNDACAO CHAMPALIM...
173K€
Perfil tecnológico estimado
Duración del proyecto: 37 meses Fecha Inicio: 2022-07-26
Fecha Fin: 2025-08-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-07-26
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021
Cerrada hace 3 años
Presupuesto El presupuesto total del proyecto asciende a 173K€
Líder del proyecto
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR.... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5