Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

NeuRemodelBehavior

Financiado

Sculpting circuits and behavior by developmental neuronal remodeling

Neuronal remodeling is a conserved strategy to refine neural circuits during development. Defects in remodeling have been associated with neuropsychiatric disorders, but direct mechanistic causality is lacking. Despite its fundame... ver más

30/04/2027

WEIZMANN

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

WEIZMANN INSTITUTE OF SCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-04-26

ERC-2021-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

WEIZMANN

2.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2019-110952GB-I00 HOUSE KEEPING GENES KEEPING EVERY NEURON DIFFERENT 109K€ Cerrado

TimeToConnect Linking time encoded in neural stem cells to neuronal networ... 196K€ Cerrado

BFU2016-81887-REDT REDEVNEURAL: UN ENFOQUE INTEGRADOR PARA ENTENDER LA LOGICA D... 20K€ Cerrado

C.NAPSE TOWARDS A COMPREHENSIVE ANALYSIS OF EXTRACELLULAR SCAFFOLDIN... 2M€ Cerrado

BFU2011-24315 ESPECIFICACION DE DESTINOS NEURONALES EN EL DESARROLLO DEL S... 237K€ Cerrado

BFU2008-00899 MECANISMOS SINAPTICOS QUE SUBYACEN AL APRENDIZAJE Y LA MEMOR... 484K€ Cerrado

Duración del proyecto: 60 meses Fecha Inicio: 2022-04-26
Fecha Fin: 2027-04-30

Líder del proyecto

WEIZMANN INSTITUTE OF SCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto Neuronal remodeling is a conserved strategy to refine neural circuits during development. Defects in remodeling have been associated with neuropsychiatric disorders, but direct mechanistic causality is lacking. Despite its fundamental significance, how remodeling of neuronal processes affects circuit architecture and function, and how this ultimately shapes behavior, is not only unknown, but also extremely challenging to study in complex organisms. Our lab is a world-leader in the molecular mechanisms of neuronal remodeling. We use the stereotypic remodeling of the Drosophila Mushroom Body (MB), a complex circuit within the fly brain, as powerful genetic model to study this question. Recently, we uncovered that MB remodeling is coordinated at the circuit level. Furthermore, we generated a detailed expression atlas of MB neurons during development, which highlighted genes and pathways mediating cell-cell interactions as prime remodeling regulators. Thus, our discoveries suggest that the time is ripe to take on the challenge of integrating the molecular, cellular, circuit and behavioral aspects of remodeling. The MB is a perfect system for this due to its well-characterized structure and function. To accomplish this goal, we will build upon our developmental expression atlas to identify molecules that mediate cell-cell interactions during remodeling (Obj 1). We will then investigate how specific genetic/cellular perturbations of remodeling impact overall circuit architecture and connectivity (Obj 2). Finally, taking a new direction for the lab, we will use behavioral readouts of MB function to understand how specific genetic perturbations of remodeling and connectivity affect circuit function and behavior (Obj 3). While each objective is independent and expected to yield high-impact discoveries by itself, it is their combined implementation that is expected to provide the first holistic picture of neuronal remodeling from molecules to cells, circuits and function.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores