Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

RHEA

Financiado

Cerrado

Rotifers Highlight the Evolution of Asexuals the mechanisms of genome evolution...

Rotifers Highlight the Evolution of Asexuals the mechanisms of genome evolution in the absence of meiosis Why sexual reproduction is overwhelmingly predominant among the metazoans remains unclear. Ancient asexual taxa are interesting model systems to gain general insights into the adaptive values of sex. The most notorious and the hig... ver más

30/09/2024

ULB

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITE LIBRE DE BRUXELLES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-09-30

ERC-2016-COG: ERC Consolidator Grant

I+D

Cerrada hace 9 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

ULB

1.07M€ | Lider

IBERICO COMARCA LOS BALDIOS

215.99K€ | Participante

UNamur

843.37K€ | Participante

Proyectos interesantes

SEXSEA

Medical Technol...

Applied Physics

1M€ Cerrado

HOTMEIOSIS

Medical Technol...

Applied Physics

2M€ Cerrado

HAPSELA

Medical Technol...

Applied Physics

1M€ Cerrado

CGL2014-53106-P

Medical Technol...

Applied Physics

186K€ Cerrado

AGL2014-52062-R

Medical Technol...

Biotechnology

133K€ Cerrado

CGL2011-26341

Medical Technol...

Applied Physics

157K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 88 meses Fecha Inicio: 2017-05-23
Fecha Fin: 2024-09-30

Líder del proyecto

UNIVERSITE LIBRE DE BRUXELLES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Why sexual reproduction is overwhelmingly predominant among the metazoans remains unclear. Ancient asexual taxa are interesting model systems to gain general insights into the adaptive values of sex. The most notorious and the highest taxonomic rank within the metazoans to reproduce asexually is the bdelloid rotifers. While studies suggest that most asexuals arose recently, the published genome of the bdelloid rotifer Adineta vaga provided the first positive evidence for the long-term ameiotic evolution of this group, confirming its ancient asexuality. How bdelloid rotifers have been able to persist despite the expected negative consequences of asexuality is the focus of this ERC proposal. I will study the mechanisms that prevent genome deterioration and promote diversification in the absence of meiotic recombination. I will include sexual rotifer sister clades in the comparison and study all components of the bdelloid lifestyle that may foster their evolution. One of the key components could be their desiccation resistance and the associated DNA double-strand breaks that appear upon prolonged desiccation. To this end, I plan to (i) sequence genomes of sexual rotifers and distinct bdelloid species that diverged a long time ago, including lineages that never experience desiccation; (ii) apply contact genomics, cellular and molecular assays, as well as targeted mutagenesis to uncover their DNA repair mechanisms; (iii) use whole-genome and RAD sequencing to perform a population genomic study of genetic exchanges among bdelloids; and (iv) investigate the function of the meiosis-specific Spo11 gene in bdelloids through targeted mutagenesis and complementation experiments. Using a computational simulation I will generate theoretical predictions on the impact of the mechanisms promoting genome evolution in asexuals. This proposal should revolutionize the field of asexual evolution and provide a new biological model system to study fundamental processes such as DNA repair.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores