Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SecMessFunctions

Financiado

Cerrado

Revealing second messenger functions in bacterial stress response, cell differe...

Revealing second messenger functions in bacterial stress response, cell differentiation and natural product biosynthesis Sophisticated signalling systems enable bacteria to occupy almost every single niche on our planet. In such systems, second messengers are crucial information carriers that elicit cellular adaptation to diverse signals. Current dy... ver más

30/06/2027

LUH

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOV... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-07-01

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

LUH

Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BIO2010-16303 CARACTERIZACION BIOMOLECULAR DE LA DIFERENCIACION DE STREPTO... 121K€ Cerrado

BFU2010-17551 CONTROL DE LA PRODUCCION DE ANTIBIOTICOS POR UN SISTEMA DE D... 109K€ Cerrado

PID2019-107716RB-I00 DESENTRAÑANDO EL PUZLE REGULATORIO DE STREPTOMYCES: NUEVAS H... 145K€ Cerrado

QUORUMPROBES An Integrated Chemical Platform to Elucidate Eukaryotic Sens... 1M€ Cerrado

SECMESSBIOFILM Cyclic di GMP New Concepts in Second Messenger Signaling an... 2M€ Cerrado

CaLiAT A novel pathway for generation of building blocks for antibi... 195K€ Cerrado

Duración del proyecto: 59 meses Fecha Inicio: 2022-07-01
Fecha Fin: 2027-06-30

Líder del proyecto

GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOV... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Sophisticated signalling systems enable bacteria to occupy almost every single niche on our planet. In such systems, second messengers are crucial information carriers that elicit cellular adaptation to diverse signals. Current dynamics in signalling research have led to the discovery of an exquisite collection of nucleotides that bacteria use as second messengers, including cyclic dimeric adenosine monophosphate (c-di-AMP). A unique feature of c-di-AMP is its essentiality, making it an attractive target for antibiotics.The main objective of this proposal is to uncover the full repertoire of c-di-AMP functions and metabolism in bacteria by using Streptomyces as a model. Streptomyces are our most prolific antibiotic producers and represent an excellent system to study multicellular differentiation. They live in soil, where they encounter diverse environmental cues that trigger antibiotic production and a complex transition from multicellular filaments to spores. c-di-AMP enables Streptomyces to survive osmotic stress caused by rainfall and drought, but interferes with development. How c-di-AMP affects differentiation and how these bacteria adapt to stress signalled by c-di-AMP is unknown.Here, we propose that bacteria use a novel transmembrane signalling pathway to remodel their cell wall for surviving stress mediated by c-di-AMP. We will challenge the current view in the field by showing that the set of enzymes involved in c-di-AMP dynamics is larger than it is currently believed and we will identify new c-di-AMP effectors. Finally, we will explore the potential of c-di-AMP for manipulation of natural product biosynthesis and address the function of a linear di-AMP molecule that is new to signalling research. Our proposed research will not only lead to the discovery of fundamental new principles in bacterial signalling and differentiation but might also identify new cell wall associated targets for drug design and tools for triggering antibiotic biosynthesis.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores