Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MCANALSMSCA2015

Financiado

Cerrado

Receptor signalling in space and time Gaining high resolution information of t...

Receptor signalling in space and time Gaining high resolution information of the temporal and spatial control of G protein coupled receptor signalling. G protein-coupled receptors (GPCRs) are the largest family of cell surface signal transducing proteins encoded by the human genome. They allow the cell to respond to diverse array of extracellular signals, control most (patho)phys... ver más

31/10/2020

THE UNIVERSITY OF...

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

THE UNIVERSITY OF NOTTINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-10-31

MSCA-IF-2015-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 9 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

THE UNIVERSITY OF NOTTINGHAM

183.45K€ | Lider

Proyectos interesantes

signalling dynamics

Medical Technol...

Applied Physics

272K€ Cerrado

NMRGPCR

Medical Technol...

Applied Physics

193K€ Cerrado

SAF2008-04943-C02-01

Medical Technol...

Applied Physics

109K€ Cerrado

SAF2008-04943-C02-02

Medical Technol...

Applied Physics

206K€ Cerrado

SAF2010-19257

Medical Technol...

Applied Physics

121K€ Cerrado

SAF2011-30216-C02-01

Medical Technol...

Applied Physics

30K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 56 meses Fecha Inicio: 2016-02-25
Fecha Fin: 2020-10-31

Líder del proyecto

THE UNIVERSITY OF NOTTINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto G protein-coupled receptors (GPCRs) are the largest family of cell surface signal transducing proteins encoded by the human genome. They allow the cell to respond to diverse array of extracellular signals, control most (patho)physiological processes, and are currently the therapeutic target of over 30% of marketed drugs. However, GPCR drug discovery is still characterised by a very high attrition rate, which reflects our inadequate understanding of the complex mechanisms of GPCR signalling and regulation. Up until recently, understanding of GPCR function was obtained from snapshots of receptors at different points in time and a major limitation for the study of GPCRs has been the inability to assess receptor activation and subsequent signalling events with high temporal (duration and frequency) or spatial (location) resolution. However, in the recent years there has been an explosion of biophysical and imaging approaches that will allow greater temporal and spatial resolution of receptor function than ever before. In this project we will measure ligand binding, receptor conformational changes, G protein activation, recruitment of regulatory proteins and receptor trafficking in real time and in live cells. We will therefore obtain detailed mechanistic understanding of the dynamics of GPCR activity in health and in disease that will reveal novel intervention points for future, more effective receptor-based therapies. This proposal combines my expertise in the study of GPCR interacting proteins and their role in receptor signalling and trafficking with the expertise of the Host Institution in the application of state-of-the-art imaging and biophysical approaches to study of this receptor family. As such, this project will not only broaden my research and technical skills in GPCR visualization, but it will also result in the establishment of a unique technological platform for the study of the dynamics of GPCR function within the Host Institution.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores