Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

NMRGPCR

Financiado

Cerrado

Structure and dynamics of G protein coupled receptors by NMR spectroscopy

"GPCRs are involved in a variety of biological and pathological processes ranging from metabolic, neurological and immune system disorders to inflammation. The members of this large family of proteins can be activated by various s... ver más

31/01/2015

PSI

193K€

Presupuesto del proyecto: 193K€

Líder del proyecto

PAUL SCHERRER INSTITUT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-01-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

PSI

0.00€ | Lider

Proyectos interesantes

JCI-2009-06040

Medical Technol...

Applied Physics

101K€ Cerrado

SAF2011-30216-C02-01

Medical Technol...

Applied Physics

30K€ Cerrado

FJC2021-046673-I

Medical Technol...

Applied Physics

65K€ Cerrado

SAF2010-19257

Medical Technol...

Applied Physics

121K€ Cerrado

SAF2008-04943-C02-01

Medical Technol...

Applied Physics

109K€ Cerrado

SAF2011-30216-C02-02

Medical Technol...

Applied Physics

24K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

PAUL SCHERRER INSTITUT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 193K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "GPCRs are involved in a variety of biological and pathological processes ranging from metabolic, neurological and immune system disorders to inflammation. The members of this large family of proteins can be activated by various stimuli including hormones, neurotransmitters, ions, odorants and light. The location of GPCRs on the cell surface and their roles as initiators in many cellular signaling pathways make them predominant drug targets. Around 30% of all drugs on the current therapeutic market function by modulating the activity of GPCRs. One of the most important topics in GPCR field is biased agonism: how different ligands induce or stabilise specific conformations of the receptor with distinct pharmacological activity. Equally important is understanding of the basis for ligand selectivity in classes of receptors with identical binding pockets. This selectivity is likely to be determined by the dynamic properties of the pocket or of the ligand entry channel. NMR spectroscopy can offer structural, dynamic and functional information at atomic resolution into molecular mechanisms of ligand recognition, biased agonism and receptor activation. The aim of the proposed research is to characterise ligand-induced conformational changes in GPCRs and the project will focus on the cannabinoid receptor (CB2), involved in immune response and sensing pain, and is overexpressed in some brain tumors. In particular, I propose a) to label CB2 for NMR analysis based on the successful mutagenesis strategy developed in the host laboratory to produce stabilised recombinant receptors for X-ray crystallography; b) to obtain a dynamic view of the conformational changes in CB2 induced by ligand binding; c) to compare the conformational changes causes by a spectrum of ligands with different activities, from antagonists to agonists. In addition, this general approach could also be extended to other difficult membrane proteins."

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores