Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CompEnz

Financiado

Cerrado

Quantum Chemistry of Enzymatic Nucleophilic Substitution Untangling the Role of...

Quantum Chemistry of Enzymatic Nucleophilic Substitution Untangling the Role of Metal Ions and Protein Environment in Biochemical Nucleophilic Substitution at Phosphorus and Sulfur Enzymatic nucleophilic substitution reactions are ubiquitous as key steps in biochemical processes of living cells. Despite their importance, they are poorly understood, in particular regarding the exact mechanism and involvement... ver más

31/10/2016

STICHTING VU

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

STICHTING VU No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-10-31 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

STICHTING VU

0.00€ | Lider

Proyectos interesantes

BES-2015-072055

Applied Physics

Medical Technol...

93K€ Cerrado

JCI-2010-08637

Applied Physics

Medical Technol...

101K€ Cerrado

COSPRODYN

Applied Physics

Medical Technol...

99K€ Cerrado

IJC2019-040468-I

Applied Physics

Medical Technol...

93K€ Cerrado

PASTIME

Applied Physics

Data Science

2M€ Cerrado

MISICD

Applied Physics

Medical Technol...

309K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

STICHTING VU No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Enzymatic nucleophilic substitution reactions are ubiquitous as key steps in biochemical processes of living cells. Despite their importance, they are poorly understood, in particular regarding the exact mechanism and involvement of the protein environment and the role and mechanistic involvement of metal ions. Through interpretative methods from chemical reactivity theory, I will tackle the missing links in this field of molecular life sciences. This project thus goes beyond transition state calculations, which are today’s state of the art in computational enzymology, by addressing the question why. The project’s goal is to build a new research protocol to give insight in enzymatic reactions. This is original and innovative, and will as such contribute to Europe’s excellence. Through the integrated scientific and complementary skills training, it will offer much to my career development. The role of metal ions and the protein environment in triphosphate hydrolysis and sulfur oxidation reactions, which are abundant and ubiquitous enzymatic reactions involved in e.g. signal and energy transduction will be untangled via quantitative molecular orbital (MO)-theory. The MO-model and its associated energy-decomposition approach, for which the host will offer a training, can make trends in reaction barriers transparent and is the current state of the art in explanatory chemistry. This approach is only marginally used to tackle the chemistry of enzymatic reactions and gives the project its originality and pioneering nature. Further, by studying the nature of the reaction barrier of sulfur oxidation reactions, I will pioneer the field of theoretical redox protein sulfur chemistry. Sulfur redox biology is being studied extensively by biochemists, but only marginally by theoreticians. In conclusion, by studying representative proteins, this project translates fundamental chemical insights into biological relevance, giving the project its interdisciplinary nature.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores