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MaintainMeth

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Quantitative analysis of DNA methylation maintenance within chromatin

Cytosine methylation is a chemical modification that is precisely copied when DNA is replicated. Because methylation can regulate gene expression, accurate reproduction of DNA methylation patterns is essential for plant and animal... ver más

31/03/2023

IST AUSTRIA

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-03-31

ERC-2016-COG: ERC Consolidator Grant

I+D

Cerrada hace 9 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

IST AUSTRIA

335.49K€ | Lider

MICRONICS THERMAL MICROSYSTE...

JOHN INNES CENTRE

2.41M€ | Participante

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Duración del proyecto: 72 meses Fecha Inicio: 2017-03-01
Fecha Fin: 2023-03-31

Líder del proyecto

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cytosine methylation is a chemical modification that is precisely copied when DNA is replicated. Because methylation can regulate gene expression, accurate reproduction of DNA methylation patterns is essential for plant and animal development and for human health. The enzymes that maintain DNA methylation have to work within chromatin, and particularly to contend with nucleosomes – tight complexes of DNA and histone proteins. How methylation of nucleosomal DNA is maintained remains unknown, and even the simple matter of whether nucleosomes hinder or promote methylation is controversial. My laboratory’s recent work with DDM1 – an ancient protein conserved between plants and animals that can move nucleosomes – and linker histone H1, which binds to nucleosomes and the intervening ‘linker’ DNA, has allowed us to formulate a model wherein movement of nucleosomes by DDM1 dislodges H1 and allows methyltransferases to access the DNA. Furthermore, this work revealed the existence of unknown factors required to maintain DNA methylation. My laboratory also discovered that DNA methylation influences nucleosome placement, thereby demonstrating that the interaction between DNA methylation and nucleosomes is bidirectional. My goal is now to deeply understand the connected processes of maintenance methylation and nucleosome placement. This will be achieved through three interconnected research strands: 1) Elucidation of how DNA methylation is maintained within chromatin. 2) Identification of new DNA methylation maintenance factors. 3) Determination of how DNA methylation influences nucleosomes in vivo. Our ultimate output will be the creation of a mathematical model of DNA methylation maintenance that will incorporate the bidirectional interactions between methylation and nucleosomes. This breakthrough will revolutionize research in the field by permitting the development of precise, quantitative hypotheses about the maintenance and function of DNA methylation within chromatin.

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