Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PrApEDoC

Financiado

Cerrado

Predicting Apoptosis Engagement Downstream of Caspases in vivo

Epithelial cell death is widespread during development and tissue homeostasis. While the core pathway of apoptosis is well known, we lack predictive power to understand when and where a specific cell will die in a tissue. Yet, thi... ver más

31/08/2028

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-07

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

2.00M€ | Lider

Proyectos interesantes

VIDEC

Medical Technol...

Biotechnology

1M€ Cerrado

MECHAIP

Medical Technol...

Applied Physics

100K€ Cerrado

EPAF

Medical Technol...

Applied Physics

2M€ Cerrado

MechDeath

Medical Technol...

Applied Physics

185K€ Cerrado

SPERMDESTRUCT

Medical Technol...

Biotechnology

2M€ Cerrado

SAF2010-19125

Medical Technol...

Applied Physics

163K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 65 meses Fecha Inicio: 2023-03-07
Fecha Fin: 2028-08-31

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Epithelial cell death is widespread during development and tissue homeostasis. While the core pathway of apoptosis is well known, we lack predictive power to understand when and where a specific cell will die in a tissue. Yet, this should have important consequences for clone selection and tissue homeostasis, as exemplified by the process of cell competition. This context dependent cell elimination is essential for tissue homeostasis and tumour progression, but we know very little about its prevalence during normal development. Recent works have characterised multiple non-apoptotic functions of effector caspases and a high frequency of cells undergoing transient caspase activation without death. Yet, what distinguishes a dying from a surviving cell downstream of effector caspase activation is completely unknown. Using quantitative live imaging of effector caspase sensors and caspase activity tuning by optogenetics in the Drosophila pupal notum (a single layer epithelium), we found that cells engage in apoptosis at very variable levels of effector caspase activity. This suggested that the engagement in apoptosis can be developmentally modulated downstream of the most terminal caspase activation and that a completely new layer of regulation of cell death could have important physiological roles. Here, we propose to combine quantitative live imaging, multivariate model, supervised machine learning and quantitative perturbations through optogenetics to define parameters predictive of the engagement in apoptosis downstream of caspase activation. We will then use spatial omics combined with an optogenetic based screening to identify new factors modulating the sensitivity to caspases. Eventually we will unravel the physiological functions of caspase sensitivity modulation by defining a new paradigm of physiological cell competition and clone selection, and characterising its impact on tissue morphogenesis and oncogenic cell elimination.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores