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Patroller monocytes as modulators of diabetic retinopathy

"Diabetic retinopathy is the first vascular complication of diabetes and the leading cause of legal blindness among adults in Europe. The fact that diabetic retinopathy is preceded by a long latency period has suggested to us that... ver más

15/05/2020

OSR

180K€

Presupuesto del proyecto: 180K€

Líder del proyecto

OSPEDALE SAN RAFFAELE SRL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-05-15

MSCA-IF-2017: Individual Fellowships

I+D

Cerrada hace 7 años

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1 Participantes

OSR

180.28K€ | Lider

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Duración del proyecto: 25 meses Fecha Inicio: 2018-04-10
Fecha Fin: 2020-05-15

Líder del proyecto

OSPEDALE SAN RAFFAELE SRL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 180K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Diabetic retinopathy is the first vascular complication of diabetes and the leading cause of legal blindness among adults in Europe. The fact that diabetic retinopathy is preceded by a long latency period has suggested to us that its natural history could incorporate a phase of vascular repair, active after short duration of diabetes and eventually losing efficacy over time. Patroller monocytes, a discrete subpopulation of circulating monocytes, patrol healthy vessels by crawling on the endothelium at a speed that is order of magnitude lower than rolling, and at variance with the ""classic"" monocyte subset produce preferentially housekeeping and trophic factors rather than inflammatory cytokines. Our preliminary data strongly support a role of patrollers, in protecting and repairing retinal vessels in diabetes; suggest that the beneficial activities are delivered during leukostasis; and indicate that 5 months of diabetes duration activates a healing/protective transcriptional program in patrollers. I seek to learn whether the biosynthetic profile of patrollers changes in relation to increasing duration of diabetes and evolving retinal vascular damage; and, most importantly, I seek to bring the study of patrollers to clinical investigation. The Objectives are to: 1. Learn if circulating patrollers adapt their biosynthetic profile to different diabetes duration (3 and 9 months) and to the evolving vascular damage 2. Bring the project to clinical applicability by start setting up a human study that aims to compare and contrast the number of circulating patrollers, as well as selected biosynthetic and functional characteristics of these cells, in T1DM patients with no DR after 4-8 years of DM, in T1DM patients with initial nonproliferative DR, and in healthy control subjects. The expectation is to capture from endogenous systems the types of molecular actions that protect the vessels in early diabetes; and thus be enabled to mimic, complement, or leverage"

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